RECRUITING

Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

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Conditions

Knee OsteoarthristisACL InjuriesPost-TraumaticPost-traumatic Knee OsteoarthritisExtracorporeal shockwave therapyacl

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is recruiting current or former athletes who had ACL reconstruction surgery over a year ago and have been diagnosed with knee osteoarthritis (OA). We are doing the research to investigate the effects of extracorporeal shockwave therapy (ESWT) on pain, function, biomechanics, knee range of motion and strength, inflammation, and joint structure and integrity of the knee.

Official Title

Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy

Quick Facts

Study Start:2025-03-07
Study Completion:2026-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06686680

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of mild to moderate PTOA based on clinical diagnosis and confirmation with radiographic evidence by a medical professional prior to study enrollment
  2. * Previous ACL reconstruction using patellar-tendon-bone autograft in the knee with PTOA
  3. * Minimum of one year following ACL reconstruction surgery
  4. * Between ages of 18 and 55
  5. * No clear contraindication to complete protocol including mechanical symptoms which would limit ability to complete the study
  6. * Score on KOOS pain subscale of \< 72
  7. * Primary pain is coming from the knee
  1. * Have previously received injections to the knee joint within the past 3 months
  2. * Women who are pregnant or those who are planning to become pregnant. This is due to the fact that pregnancy will reduce participants activity after the treatment and the safety concerns related to shockwave treatment. - Participants with neuropathy affecting sensation to pain
  3. * Participants with a known underlying cardiac disease that could be affected by shockwave therapy
  4. * Chronic rheumatological conditions, immunodeficiency, severe asthma, connective tissue disorder (i.e. Ehlers-Danlos Syndrome), or other medical conditions (ex. active malignancy, severe asthma) outside of PTOA that are known to impact inflammatory state or requiring chronic use of oral or intravenous immune modulatory medications. Asthma requiring use of inhalers only is not an exclusion criteria
  5. * Neuropathy diagnosis that can affect response to pain
  6. * No active use of oral steroids or anti-inflammatories at the time of enrollment
  7. * Have bilateral ACL injury or reconstruction surgery, or have had ACL revision surgery
  8. * No active malignancy and at least five years in remission
  9. * Previous ESWT treatment using study treatment devices for management of knee osteoarthritis
  10. * Have a pacemaker, bone screws, or any other metal implants that would prohibit participation in an MRI scan or EWST
  11. * Non-English speaking individuals

Contacts and Locations

Study Contact

Adam S Tenforde, MD
CONTACT
(617) 952-6800
atenforde@mgh.harvard.edu

Study Locations (Sites)

Spaulding Cambridge Hospital
Cambridge, Massachusetts, 02138
United States

Collaborators and Investigators

Sponsor: Spaulding Rehabilitation Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-07
Study Completion Date2026-09

Study Record Updates

Study Start Date2025-03-07
Study Completion Date2026-09

Terms related to this study

Keywords Provided by Researchers

  • Post-traumatic Knee Osteoarthritis
  • Extracorporeal shockwave therapy
  • acl

Additional Relevant MeSH Terms

  • Knee Osteoarthristis
  • ACL Injuries
  • Post-Traumatic