ENROLLING_BY_INVITATION

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Conditions

Brain Activity Related to Opioid Administration Brain Activity Related to Drug Liking opioid crisis neuroscience EEG drug liking fentanyl anesthesia general anesthesia opioids analgesia

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Official Title

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Quick Facts

Study Start:2025-02-04

Study Completion:2026-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ENROLLING_BY_INVITATION

Study ID

NCT06699953

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. 18 years old or above (male and female) 2. American Society of Anesthesiologists (ASA) physical status classification of I, II or III 3. Candidates scheduled for general surgical procedures under general anesthesia and receive fentanyl for surgery	1. Craniofacial abnormalities 2. Known or suspected difficult intubation or mask ventilation 3. Known or suspected need for rapid sequence induction and intubation 4. Body mass index above 45 kg/m2 5. Allergies to fentanyl 6. History of obstructive sleep apnea requiring CPAP 7. History of obstructive or restrictive lung disease 8. Opiate use within 24 hours 9. History of opiate abuse within the last 3 years 10. Known or suspected severe chronic pain condition that require use of opiates or limit daily activities 11. MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body

Inclusion Criteria

Exclusion Criteria

1. 18 years old or above (male and female)
2. American Society of Anesthesiologists (ASA) physical status classification of I, II or III
3. Candidates scheduled for general surgical procedures under general anesthesia and receive fentanyl for surgery

1. Craniofacial abnormalities
2. Known or suspected difficult intubation or mask ventilation
3. Known or suspected need for rapid sequence induction and intubation
4. Body mass index above 45 kg/m2
5. Allergies to fentanyl
6. History of obstructive sleep apnea requiring CPAP
7. History of obstructive or restrictive lung disease
8. Opiate use within 24 hours
9. History of opiate abuse within the last 3 years
10. Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
11. MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body

Contacts and Locations

Study Locations (Sites)

Stanford Hospital

Palo Alto, California, 94304

United States

Collaborators and Investigators

Sponsor: Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-04

Study Completion Date2026-12-31

Study Record Updates

Study Start Date2025-02-04

Study Completion Date2026-12-31

Terms related to this study

Keywords Provided by Researchers

opioid crisis
neuroscience
EEG
drug liking
fentanyl
anesthesia
general anesthesia
opioids
analgesia

Additional Relevant MeSH Terms

Brain Activity Related to Opioid Administration
Brain Activity Related to Drug Liking