Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Description

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Conditions

Brain Activity Related to Opioid Administration, Brain Activity Related to Drug Liking

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Study Overview

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Study Details

Study overview

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

Condition
Brain Activity Related to Opioid Administration
Intervention / Treatment

-

Contacts and Locations

Palo Alto

Stanford Hospital, Palo Alto, California, United States, 94304

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 18 years old or above (male and female)
  • 2. American Society of Anesthesiologists (ASA) physical status classification of I, II or III
  • 3. Candidates scheduled for general surgical procedures under general anesthesia and receive fentanyl for surgery
  • 1. Craniofacial abnormalities
  • 2. Known or suspected difficult intubation or mask ventilation
  • 3. Known or suspected need for rapid sequence induction and intubation
  • 4. Body mass index above 45 kg/m2
  • 5. Allergies to fentanyl
  • 6. History of obstructive sleep apnea requiring CPAP
  • 7. History of obstructive or restrictive lung disease
  • 8. Opiate use within 24 hours
  • 9. History of opiate abuse within the last 3 years
  • 10. Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
  • 11. MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Study Record Dates

2026-11-30