RECRUITING

Cardiovascular Responses in Burn Survivors During Exercise

Description

This project will identify the efficacy of cooling modalities aimed to attenuate excessive elevations in skin and internal body temperatures, and associated indices of cardiovascular stress, during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects and subjects who experienced burns covering 20% or more of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling (control) as well as skin wetting.

Conditions

Study Overview

Study Details

Study overview

This project will identify the efficacy of cooling modalities aimed to attenuate excessive elevations in skin and internal body temperatures, and associated indices of cardiovascular stress, during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects and subjects who experienced burns covering 20% or more of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling (control) as well as skin wetting.

Cardiovascular Responses in Burn Survivors During Exercise

Cardiovascular Responses in Burn Survivors During Exercise

Condition
Burn Injury
Intervention / Treatment

-

Contacts and Locations

Dallas

Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas, Dallas, Texas, United States, 75231

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy male and female subjects
  • * 18-65 years of age.
  • * Free of any underlying medical conditions
  • * Any burn-related injuries resulting in at least one night of hospitalization.
  • * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.
  • * Abnormalities detected on routine screening
  • * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
  • * Current smokers, as well as individuals who regularly smoked within the past 3 years.
  • * Body mass index of greater than 30 kg/m\^2.
  • * Pregnant individuals

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Craig G Crandall, PhD, PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center

Study Record Dates

2027-01-01