RECRUITING

Cardiovascular Responses in Burn Survivors During Exercise

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This project will identify the efficacy of cooling modalities aimed to attenuate excessive elevations in skin and internal body temperatures, and associated indices of cardiovascular stress, during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects and subjects who experienced burns covering 20% or more of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling (control) as well as skin wetting.

Official Title

Cardiovascular Responses in Burn Survivors During Exercise

Quick Facts

Study Start:2024-07-31
Study Completion:2027-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06709781

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Healthy male and female subjects
  2. * 18-65 years of age.
  3. * Free of any underlying medical conditions
  1. * Any burn-related injuries resulting in at least one night of hospitalization.
  2. * Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.
  3. * Abnormalities detected on routine screening
  4. * Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
  5. * Current smokers, as well as individuals who regularly smoked within the past 3 years.
  6. * Body mass index of greater than 30 kg/m\^2.
  7. * Pregnant individuals

Contacts and Locations

Study Contact

Erin M Harper, B.S.
CONTACT
214-345-4737
erinharper@texashealth.org
Craig G Crandall, PhD
CONTACT
214-345-4623
craigcrandall@texashealth.org

Principal Investigator

Craig G Crandall, PhD
PRINCIPAL_INVESTIGATOR
UT Southwestern Medical Center

Study Locations (Sites)

Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas, 75231
United States

Collaborators and Investigators

Sponsor: University of Texas Southwestern Medical Center

  • Craig G Crandall, PhD, PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-07-31
Study Completion Date2027-01-01

Study Record Updates

Study Start Date2024-07-31
Study Completion Date2027-01-01

Terms related to this study

Keywords Provided by Researchers

  • skin graft
  • thermoregulation
  • burn survivor
  • 3rd degree burn injury
  • human
  • cooling

Additional Relevant MeSH Terms

  • Burn Injury