RECRUITING

Noninvasive Brain Stimulation in Adult Amblyopia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this randomized controlled trial is to investigate the effectiveness of non-invasive brain stimulation in treating adults with amblyopia. The main questions it aims to answer are: 1. What are the effects of non-invasive brain stimulation on neuronal plasticity in the visual cortex of adults with amblyopia, and does it produce lasting changes? 2. Do cumulative sessions of non-invasive brain stimulation influence neural plasticity and higher-order visual functions in adults with amblyopia? The investigators hypothesize that non-invasive brain stimulation will show a positive cumulative effect after five (5) consecutive days of stimulation on visual perception and function in adults with amblyopia. Participants will be randomized into one of two treatment groups: 1. High-frequency transcranial random noise stimulation (hf-tRNS). 2. Sham stimulation. Researchers will compare baseline measurements of crowded visual acuity, contrast sensitivity, stereoacuity, phosphene thresholds, global motion perception, form pattern recognition and pattern-reversal visual evoked potentials (VEPs) to post-treatment measurements for each group.

Official Title

Multi-day Effect of Noninvasive Brain Stimulation in Adults with Amblyopia

Quick Facts

Study Start:2024-05-01
Study Completion:2028-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06712849

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults between 18 and 55 years of age
  2. * Formal diagnosis of amblyopia in one or both eyes of any etiology
  1. * History of optic nerve disease, including glaucoma and optic neuritis
  2. * History of neurological conditions, including demyelinating disease or stroke
  3. * Presence of metal or electronic implants in or on the body, including pacemakers
  4. * Taking medications that can affect normal neurological function, including antipsychotics, antiepileptics, and opioids

Contacts and Locations

Study Contact

Arijit Chakraborty, PhD
CONTACT
630-960-3172
achakr@midwestern.edu
Adrienne C Quan, OD
CONTACT
630-960-3183
aquan@midwestern.edu

Study Locations (Sites)

Midwestern University Eye Institute
Downers Grove, Illinois, 60515
United States

Collaborators and Investigators

Sponsor: Midwestern University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-05-01
Study Completion Date2028-12-31

Study Record Updates

Study Start Date2024-05-01
Study Completion Date2028-12-31

Terms related to this study

Keywords Provided by Researchers

  • Amblyopia
  • Non-invasive Brain Stimulation
  • Transcranial Random Noise Stimulation
  • Visual Perception
  • Visual Evoked Potentials

Additional Relevant MeSH Terms

  • Amblyopia