ACTIVE_NOT_RECRUITING

A Study to Test Whether BI 771716 Helps People With an Advanced Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is open to people 50 years or older with an eye condition called geographic atrophy. The purpose of this study is to compare a medicine called BI 771716 with a medicine called pegcetacoplan. BI 771716 is being developed to treat people with geographic atrophy. Pegcetacoplan is a medicine already used to treat people with geographic atrophy. In this study, participants receive either BI 771716 or pegcetacoplan as injections in the eye. Participants are in the study for a little longer than a year and visit the study site every 4 weeks. At the visits, the study doctor checks the eyes of the participants. The results are compared between the groups of participants to see whether the treatment works. The study doctor also regularly checks participants' health and takes note of any unwanted effects.

Official Title

Randomized, Double-masked, Active-controlled, Multicenter Study to Evaluate Efficacy and Safety of Two Regimens of Intravitreal BI 771716 Against Pegcetacoplan in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration VERDANT Trial

Quick Facts

Study Start:2025-01-06
Study Completion:2026-10-16
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06722157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Locations (Sites)

Associated Retina Consultants
Gilbert, Arizona, 85297
United States
Associated Retina Consultants, Ltd.
Phoenix, Arizona, 85020
United States
Phoenix Retina Associates
Phoenix, Arizona, 85050
United States
Retina Macula Institute of Arizona
Scottsdale, Arizona, 85255
United States
Global Research Management
Glendale, California, 91204
United States
Retina Associates of Southern California
Huntington Beach, California, 92647
United States
Retinal Consultants Medical Group, Inc
Modesto, California, 95356
United States
Eye Research Foundation
Newport Beach, California, 92663
United States
Retina Consultants of San Diego
Poway, California, 92064
United States
Retinal Consultants Medical Group
Sacramento, California, 95825
United States
Bay Area Retina Associates - Walnut Creek
Walnut Creek, California, 94598
United States
Colorado Retina Associates
Lakewood, Colorado, 80228
United States
Connecticut Eye Consultants, PC
Danbury, Connecticut, 06810
United States
Retina Group of New England, PC
Waterford, Connecticut, 06385
United States
Rand Eye Institute
Deerfield Beach, Florida, 33064
United States
Retina Group of Florida
Fort Lauderdale, Florida, 33308
United States
Eye Associates of Pinellas
Pinellas Park, Florida, 33782
United States
Retina Vitreous Associates of Florida
St. Petersburg, Florida, 33711
United States
Southeast Retina Center, PC
Augusta, Georgia, 30909
United States
University Retina and Macula Associates
Lemont, Illinois, 60439
United States
Illinois Retina Associates - Oak Park
Oak Park, Illinois, 60304
United States
Butchertown Clinical Trials
Louisville, Kentucky, 40206
United States
Mid Atlantic Retina Specialists
Hagerstown, Maryland, 21740
United States
Ophthalmic Consultants of Boston
Boston, Massachusetts, 02114
United States
Retina Consultants of Minnesota
Edina, Minnesota, 55435
United States
Mississippi Retina Associates
Madison, Mississippi, 39110
United States
University of Missouri Health System
Columbia, Missouri, 65212
United States
Envision Ocular, LLC
Bloomfield, New Jersey, 07003
United States
Eye Associates of New Mexico
Albuquerque, New Mexico, 87109
United States
Long Island Vitreoretinal Consultants - Westbury
Westbury, New York, 11590
United States
Verum Research, LLC
Eugene, Oregon, 97401
United States
Mid Atlantic Retina - Bethlehem
Bethlehem, Pennsylvania, 18017
United States
Charleston Neuroscience Institute - Charleston
Charleston, South Carolina, 29414
United States
Charles Retina Institute
Germantown, Tennessee, 38138
United States
Tennessee Retina
Nashville, Tennessee, 37203
United States
Austin Clinical Research, LLC
Austin, Texas, 78750
United States
Retina Consultants of Texas-Beaumont-70319
Beaumont, Texas, 77707
United States
Retina Consultants of Texas-Bellaire-67493
Bellaire, Texas, 77401
United States
Retina Foundation of the Southwest
Dallas, Texas, 75231
United States
Retina Consultants of Texas - Katy
Katy, Texas, 77494
United States
Red River Research Partners, LLC
Plano, Texas, 75024
United States
Retinal Consultants of San Antonio
San Antonio, Texas, 78240
United States
Retina Consultants of Texas - Schertz
Schertz, Texas, 78154
United States
Retina Consultants of Texas-The Woodlands-67575
The Woodlands, Texas, 77384
United States
Retina Associates of Utah
Salt Lake City, Utah, 84107
United States
Piedmont Eye Center
Lynchburg, Virginia, 24502
United States
Spokane Eye Clinic
Spokane, Washington, 99204
United States

Collaborators and Investigators

Sponsor: Boehringer Ingelheim

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-06
Study Completion Date2026-10-16

Study Record Updates

Study Start Date2025-01-06
Study Completion Date2026-10-16

Terms related to this study

Additional Relevant MeSH Terms

  • Macular Degeneration, Age-related
  • Geographic Atrophy