RECRUITING

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

Description

This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.

Study Overview

Study Details

Study overview

This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.

A Pilot Randomized Controlled Trial Assessing Pain and Opioid Outcomes Among Patients Undergoing Total Knee Arthroplasty Receiving 5-Day Outpatient Adductor Canal Continuous Versus Single Injection Blocks

Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty

Condition
Acute Postoperative Pain
Intervention / Treatment

-

Contacts and Locations

La Jolla

University of California, San Diego, La Jolla, California, United States, 92037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adult participants of at least 18 years of age
  • 2. Undergoing a primary, unilateral, total knee arthroplasty
  • 3. Planned single-injection adductor canal nerve block
  • 4. Weight \> 50 kg (to minimize the risk of local anesthetic toxicity)
  • 1. chronic opioid or tramadol use: daily oxycodone equivalents \> 20 mg for \> 4 weeks
  • 2. neuro-muscular deficit of the surgical limb
  • 3. moderate pain (NRS \> 3) in an anatomic location other than the surgical site
  • 4. planned hospital admission following surgery
  • 5. history of opioid misuse
  • 6. those who lack capacity to complete informed consent
  • 7. inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)
  • 8. incarceration
  • 9. pregnancy
  • 10. allergy to amide local anesthetics

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Study Record Dates

2025-12-01