RECRUITING

Role of Menopause in Thermoregulation

Description

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Conditions

Study Overview

Study Details

Study overview

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

The Influence of Estrogen on the Thermoregulatory Responses to Heat Stress in Pre and Postmenopausal Women

Role of Menopause in Thermoregulation

Condition
Menopause
Intervention / Treatment

-

Contacts and Locations

University Park

Noll Laboratory, University Park, Pennsylvania, United States, 16802

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Women ages 42-64
  • * Chron's disease, diverticulitis, or similar gastrointestinal disease
  • * Abnormal resting exercise electrocardiogram (ECG)
  • * Tobacco use
  • * High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor
  • * Assessment
  • * Using hormone therapy
  • * Using hormonal contraceptives

Ages Eligible for Study

42 Years to 64 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Penn State University,

W. Larry Kenney, Ph.D., PRINCIPAL_INVESTIGATOR, The Pennsylvania State University

Study Record Dates

2026-07-01