RECRUITING

Role of Menopause in Thermoregulation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Official Title

The Influence of Estrogen on the Thermoregulatory Responses to Heat Stress in Pre and Postmenopausal Women

Quick Facts

Study Start:2025-03-01
Study Completion:2026-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06798571

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:42 Years to 64 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Women ages 42-64
  1. * Chron's disease, diverticulitis, or similar gastrointestinal disease
  2. * Abnormal resting exercise electrocardiogram (ECG)
  3. * Tobacco use
  4. * High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor
  5. * Assessment
  6. * Using hormone therapy
  7. * Using hormonal contraceptives

Contacts and Locations

Study Contact

W. Larry Kenney, Ph.D.
CONTACT
814-863-1672
w7k@psu.edu
Olivia K. Leach, MS
CONTACT
okl5046@psu.edu

Principal Investigator

W. Larry Kenney, Ph.D.
PRINCIPAL_INVESTIGATOR
The Pennsylvania State University

Study Locations (Sites)

Noll Laboratory
University Park, Pennsylvania, 16802
United States

Collaborators and Investigators

Sponsor: Penn State University

  • W. Larry Kenney, Ph.D., PRINCIPAL_INVESTIGATOR, The Pennsylvania State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-01
Study Completion Date2026-07-01

Study Record Updates

Study Start Date2025-03-01
Study Completion Date2026-07-01

Terms related to this study

Keywords Provided by Researchers

  • Thermoregulation
  • Heat Stress

Additional Relevant MeSH Terms

  • Menopause
  • Aging