RECRUITING

QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is to create a test that can accurately find and measure the problem areas in muscle and fascia tissue, also known as myofascial pain. The hypothesis is that a combination of imaging findings will be able to detect when myofascial pain is present. The goal is to improve management of myofascial pain by making better tools to find changes in the muscle and fascia tissues for a more personalized treatment. This project was funded by the HEAL initiative (https://heal.nih.gov/).

Official Title

QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers

Quick Facts

Study Start:2025-04
Study Completion:2026-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06803056

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. * Younger than 18 years of age
  2. * History of an invasive procedures to the foot and ankle or history of lower extremity injections within past 3 months
  3. * Contraindications for MRI (e.g. non-MR compatible implanted devices, claustrophobia, inability to remain still comfortably for 1 hour in a supine position, body size too large for MR scanner)
  4. * Clinically unstable medical or psychiatric issues
  5. * Co-morbidities associated with changes in musculoskeletal imaging, including rheumatological conditions (e.g., rheumatoid arthritis, spondyloarthropathy), osteoarthritis of the foot or ankle, diabetes, neuromuscular diseases (e.g., Charcot-Marie-Tooth), familial hypercholesterolemia, history of foot or ankle fracture, neoplasms involving the foot, plantar fibromatosis, recent (within the past 1 year) infection of the foot or ankle (e.g., infectious fasciitis, calcaneal osteomyelitis).
  6. * Control group only: Persistent or recurrent leg pain in the past 6 months
  7. * Plantar fasciitis and Achilles tendinopathy groups only: Other source of heel or foot pain (e.g., tarsal tunnel syndrome, peripheral neuropathy, lumbar radiculopathy, calcaneal stress fracture, Morton's neuroma, fibromyalgia) or co-occurring plantar fasciitis and Achilles tendinopathy.

Contacts and Locations

Study Contact

Jing Danielson, DDS
CONTACT
319-356-1722
chimenti-lab@uiowa.edu
Jessica Danielson, DDS
CONTACT
319-356-9791
chimenti-lab@uiowa.edu

Principal Investigator

Kathleen Sluka, PT, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa
James Holmes, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa
Ruth L Chimenti, PT, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa

Study Locations (Sites)

University of Iowa Health Care
Iowa City, Iowa, 52242
United States

Collaborators and Investigators

Sponsor: Ruth Chimenti

  • Kathleen Sluka, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa
  • James Holmes, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa
  • Ruth L Chimenti, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04
Study Completion Date2026-08

Study Record Updates

Study Start Date2025-04
Study Completion Date2026-08

Terms related to this study

Keywords Provided by Researchers

  • plantar fasciitis
  • achilles tendinitis
  • biomarker
  • myofascial
  • magnetic resonance imaging
  • ultrasound imaging
  • pain

Additional Relevant MeSH Terms

  • Plantar Fasciopathy
  • Achilles Tendinopathy
  • Controls