QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers

Description

This study is to create a test that can accurately find and measure the problem areas in muscle and fascia tissue, also known as myofascial pain. The hypothesis is that a combination of imaging findings will be able to detect when myofascial pain is present. The goal is to improve management of myofascial pain by making better tools to find changes in the muscle and fascia tissues for a more personalized treatment. This project was funded by the HEAL initiative (https://heal.nih.gov/).

Conditions

Plantar Fasciopathy, Achilles Tendinopathy, Controls

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Study Overview

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Study Details

Study overview

This study is to create a test that can accurately find and measure the problem areas in muscle and fascia tissue, also known as myofascial pain. The hypothesis is that a combination of imaging findings will be able to detect when myofascial pain is present. The goal is to improve management of myofascial pain by making better tools to find changes in the muscle and fascia tissues for a more personalized treatment. This project was funded by the HEAL initiative (https://heal.nih.gov/).

QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers

QUANTIFY: Quantitative Understanding of Advanced Novel Techniques for Imaging Fasciitis and Yielding Biomarkers

Condition
Plantar Fasciopathy
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa Health Care, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Younger than 18 years of age
  • * History of an invasive procedures to the foot and ankle or history of lower extremity injections within past 3 months
  • * Contraindications for MRI (e.g. non-MR compatible implanted devices, claustrophobia, inability to remain still comfortably for 1 hour in a supine position, body size too large for MR scanner)
  • * Clinically unstable medical or psychiatric issues
  • * Co-morbidities associated with changes in musculoskeletal imaging, including rheumatological conditions (e.g., rheumatoid arthritis, spondyloarthropathy), osteoarthritis of the foot or ankle, diabetes, neuromuscular diseases (e.g., Charcot-Marie-Tooth), familial hypercholesterolemia, history of foot or ankle fracture, neoplasms involving the foot, plantar fibromatosis, recent (within the past 1 year) infection of the foot or ankle (e.g., infectious fasciitis, calcaneal osteomyelitis).
  • * Control group only: Persistent or recurrent leg pain in the past 6 months
  • * Plantar fasciitis and Achilles tendinopathy groups only: Other source of heel or foot pain (e.g., tarsal tunnel syndrome, peripheral neuropathy, lumbar radiculopathy, calcaneal stress fracture, Morton's neuroma, fibromyalgia) or co-occurring plantar fasciitis and Achilles tendinopathy.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ruth Chimenti,

Kathleen Sluka, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

James Holmes, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Ruth L Chimenti, PT, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2026-08