RECRUITING

Flu Infection at UPHS

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Influenza HumanFlu Infection at UPHS

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Cellular and humoral immune responses in individuals with active influenza infection will be assessed. Each year, up to 50 participants will be enrolled. The investigators hypothesize that influenza infection will elicit mostly memory immune responses rather than de novo immune responses to infection.

Official Title

Evaluating Immune Imprinting in the Context of Influenza Virus Infections

Quick Facts

Study Start:2025-01-27
Study Completion:2026-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06807840

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Provision of signed and dated informed consent form
  2. 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  3. 3. Aged 18 years and older
  4. 4. Influenza positive test result performed within the University of Pennsylvania Health System
  1. 1. Known latex allergy
  2. 2. Immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months
  3. 3. Pregnancy due to the volume of blood collected in this study
  4. 4. Treatment with immunoglobulin or another blood product within the 3 months prior to enrollment in this study
  5. 5. Any neoplastic disease (excluding non-melanoma skin cancer or prostate cancer that is stable in the absence of therapy) or a history of any hematological malignancy ("active" is defined as having received treatment within the past 5 years)
  6. 6. Known acute or chronic medical condition that, in the opinion of the investigator or appropriate sub-investigator, would interfere with the evaluation of immune responses
  7. 7. Intends to donate blood during the study period
  8. 8. A known human immunodeficiency virus, hepatitis B, or hepatitis C infection
  9. 9. Any condition that would, in the opinion of the site investigator, place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol
  10. 10. Prolonged inpatient hospitalization that disrupts or interferes with study procedures.
  11. 11. Weigh less than 110lbs

Contacts and Locations

Study Contact

Scott Hensley, PhD
CONTACT
215-573-3756
hensley@pennmedicine.upenn.edu
Elizabeth Drapeau, PhD
CONTACT
215-573-3756
elizabeth.troisi@pennmedicine.upenn.edu

Study Locations (Sites)

Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104
United States

Collaborators and Investigators

Sponsor: University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-27
Study Completion Date2026-09-30

Study Record Updates

Study Start Date2025-01-27
Study Completion Date2026-09-30

Terms related to this study

Keywords Provided by Researchers

  • Flu Infection at UPHS

Additional Relevant MeSH Terms

  • Influenza Human