Flu Infection at UPHS

Description

Cellular and humoral immune responses in individuals with active influenza infection will be assessed. Each year, up to 50 participants will be enrolled. The investigators hypothesize that influenza infection will elicit mostly memory immune responses rather than de novo immune responses to infection.

Conditions

Influenza Human

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Study Overview

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Study Details

Study overview

Cellular and humoral immune responses in individuals with active influenza infection will be assessed. Each year, up to 50 participants will be enrolled. The investigators hypothesize that influenza infection will elicit mostly memory immune responses rather than de novo immune responses to infection.

Evaluating Immune Imprinting in the Context of Influenza Virus Infections

Flu Infection at UPHS

Condition
Influenza Human
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Provision of signed and dated informed consent form
  • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 3. Aged 18 years and older
  • 4. Influenza positive test result performed within the University of Pennsylvania Health System
  • 1. Known latex allergy
  • 2. Immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months
  • 3. Pregnancy due to the volume of blood collected in this study
  • 4. Treatment with immunoglobulin or another blood product within the 3 months prior to enrollment in this study
  • 5. Any neoplastic disease (excluding non-melanoma skin cancer or prostate cancer that is stable in the absence of therapy) or a history of any hematological malignancy ("active" is defined as having received treatment within the past 5 years)
  • 6. Known acute or chronic medical condition that, in the opinion of the investigator or appropriate sub-investigator, would interfere with the evaluation of immune responses
  • 7. Intends to donate blood during the study period
  • 8. A known human immunodeficiency virus, hepatitis B, or hepatitis C infection
  • 9. Any condition that would, in the opinion of the site investigator, place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol
  • 10. Prolonged inpatient hospitalization that disrupts or interferes with study procedures.
  • 11. Weigh less than 110lbs

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

Study Record Dates

2026-09-30