RECRUITING

Role of Transposable Elements in Septic Immune Aging

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.

Official Title

Role of Transposable Elements in Septic Immune Aging

Quick Facts

Study Start:2025-02-14
Study Completion:2026-08-14
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06809868

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 or older
  2. * Admitted to ICU with sepsis (Sepsis 3 Criteria)
  3. * SOFA score of at least 2 at time of enrollment
  1. * Patients on organ transplantation immunosuppression
  2. * Patients with preexisting leukopenia
  3. * Cancer patients receiving CAR-T therapy
  4. * Patients who are under 18 years of age or otherwise deemed pediatric
  5. * Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock)
  6. * Patients with a chronic hemoglobin below 7.0
  7. * Patients who, prior to their ICU admission, are blood transfusion dependent

Contacts and Locations

Study Contact

Alexendar R Perez, M.D., Ph.D
CONTACT
415-476-1000
Alexendar.Perez@ucsf.edu
Matthieu Legrand, M.D., Ph.D
CONTACT
415-476-1000
matthieu.legrand@ucsf.edu

Principal Investigator

Alexendar R Perez, M.D., Ph.D
PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Judith Hellman, M.D.
PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Matthieu Legrand, M.D., Ph.D
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California, San Francisco
San Francisco, California, 94143
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Alexendar R Perez, M.D., Ph.D, PRINCIPAL_INVESTIGATOR, University of California, San Francisco
  • Judith Hellman, M.D., PRINCIPAL_INVESTIGATOR, University of California, San Francisco
  • Matthieu Legrand, M.D., Ph.D, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-14
Study Completion Date2026-08-14

Study Record Updates

Study Start Date2025-02-14
Study Completion Date2026-08-14

Terms related to this study

Keywords Provided by Researchers

  • Sepsis
  • Transposable Elements
  • Immune Aging
  • Mortality
  • Secondary Infections
  • Critical Care Medicine (ICU)

Additional Relevant MeSH Terms

  • Sepsis
  • Sepsis and Septic Shock
  • Sepsis With Multiple Organ Dysfunction (MOD)
  • Sepsis With Acute Organ Dysfunction
  • Sepsis, Severe
  • Sepsis at Intensive Care Unit
  • Sepsis, Severe Sepsis and Septic Shock
  • Sepsis, Septic Shock