Role of Transposable Elements in Septic Immune Aging

Description

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.

Conditions

Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction, Sepsis, Severe, Sepsis at Intensive Care Unit, Sepsis, Severe Sepsis and Septic Shock, Sepsis, Septic Shock

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Study Overview

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Study Details

Study overview

The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.

Role of Transposable Elements in Septic Immune Aging

Role of Transposable Elements in Septic Immune Aging

Condition
Sepsis
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 or older
  • * Admitted to ICU with sepsis (Sepsis 3 Criteria)
  • * SOFA score of at least 2 at time of enrollment
  • * Patients on organ transplantation immunosuppression
  • * Patients with preexisting leukopenia
  • * Cancer patients receiving CAR-T therapy
  • * Patients who are under 18 years of age or otherwise deemed pediatric
  • * Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock)
  • * Patients with a chronic hemoglobin below 7.0
  • * Patients who, prior to their ICU admission, are blood transfusion dependent

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, San Francisco,

Alexendar R Perez, M.D., Ph.D, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Judith Hellman, M.D., PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Matthieu Legrand, M.D., Ph.D, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-08-14