RECRUITING

Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

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Conditions

EndometriosisEndometriomaEndometrial biopsy

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy

Official Title

Mechanisms of Uterine Fluid Absorption During Early Pregnancy

Quick Facts

Study Start:2025-02-01
Study Completion:2030-02-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06847685

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Subject must be a healthy woman between the ages of 18 and 45 years.
  2. 2. Women with diagnosed endometriosis or infertility (cases).
  3. 3. Women without a diagnosis of endometriosis or infertility (controls).
  4. 4. Subject must have regular menstrual cycles.
  5. 5. Subject must have a body mass index (BMI) between 18 and 40.
  6. 6. Subject must be or have been sexually active or have had a previous vaginal exam that used a speculum.
  7. 7. Subject must be able to understand and provide consent to procedures and use/disclosure of protected health information.
  8. 8. No history of Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, hepatitis B, and HIV.
  9. 9. For IVF study subjects, a minimum endometrial thickness of 7mm at the time of sample collection.
  1. 1. Pregnant women.
  2. 2. Study subjects with endometrial cancer.
  3. 3. Study subjects with a history of endometrial ablation.
  4. 4. Study subjects with undiagnosed uterine bleeding.
  5. 5. Women with reproductive diseases that affect the endometrium (such as fibroids or uterine polyps that distort endometrial cavity).
  6. 6. Study subjects with an intrauterine device (IUD).

Contacts and Locations

Study Contact

James Segars, MD
CONTACT
410-614-2000
jsegars2@jhmi.edu
Bhuchitra Singh, MD, MPH, MS, MBA
CONTACT
410-614-2000
bsingh10@jhmi.edu

Principal Investigator

James Segars, MD
PRINCIPAL_INVESTIGATOR
Johns Hopkins University
Bhuchitra Singh, MD, MPH, MS, MBA
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Johns Hopkins Hospital
Baltimore, Maryland, 21287
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • James Segars, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University
  • Bhuchitra Singh, MD, MPH, MS, MBA, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-01
Study Completion Date2030-02-01

Study Record Updates

Study Start Date2025-02-01
Study Completion Date2030-02-01

Terms related to this study

Keywords Provided by Researchers

  • Endometriosis
  • Endometrial biopsy

Additional Relevant MeSH Terms

  • Endometriosis
  • Endometrioma