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The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

Description

This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.

Conditions

Ischemic Heart Disease (IHD)Cardiac Magnetic Resonance ImagingMyocardial Blood Flow
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Related Conditions:

Ischemic Heart Disease (IHD)Cardiac Magnetic Resonance ImagingMyocardial Blood Flow

Study Overview

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Study Details

Study overview

This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States (SPINS2) Study

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

Condition
Ischemic Heart Disease (IHD)
Intervention / Treatment

-

Contacts and Locations

Boston

Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. male or female at age 35-85 years,
  • 2. presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:
  • 1. chest pain or anginal equivalent, or
  • 2. abnormal electrocardiogram with a suspicion of coronary artery disease
  • 3. Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions:
  • 1. Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
  • 2. Confirmed diagnosis of any significant non-coronary cardiac conditions below:
  • 1. any severe-grade valvular heart disease,
  • 2. left ventricular ejection fraction \<40% from any known non-coronary causes,
  • 3. infiltrative cardiomyopathy,
  • 4. hypertrophic cardiomyopathy,
  • 5. pericardial disease with significant constriction, or
  • 3. active pregnancy,
  • 4. any competing conditions leading to an expected survival of \< 2 years
  • 5. contraindication to vasodilator (regadenoson or adenosine)
  • 6. metallic device or object that poses an magnetic resonance imaging safety hazard
  • 7. metallic device with a high likelihood of non-diagnostic cardiac magnetic resonance images

Ages Eligible for Study

35 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Brigham and Women's Hospital,

Study Record Dates

2029-03