RECRUITING

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research aims to investigate whether symptoms of chest pain or shortness of breath among the study population are arising due to a heart problem, particularly any reduction of blood flow to the heart muscle from blockages in the coronary blood vessels or inflammation of the heart using cardiac magnetic resonance imaging that measures the amount of blood flow during a stress state meant to simulate vigorous exercise. At present, doctors use standard magnetic resonance imaging pictures of blood flow patterns to treat heart disease. The investigators want to study if detailed blood flow measurements, in addition to the standard blood flow pattern, could diagnose heart disease more accurately and allow more doctors to understand the severity of heart disease. Early research has demonstrated that detailed blood flow measurements may be more accurate in diagnosing heart disease in some patients, but doctors need more information to know how to use these measurements.

Official Title

The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States (SPINS2) Study

Quick Facts

Study Start:2025-06-27
Study Completion:2029-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06854458

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:35 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. male or female at age 35-85 years,
  2. 2. presence of either of the following sign/symptom that led to a referral to stress cardiac magnetic resonance imaging:
  3. 1. chest pain or anginal equivalent, or
  4. 2. abnormal electrocardiogram with a suspicion of coronary artery disease
  5. 3. Intermediate or high risk of significant coronary disease based on at least 1 of the following conditions:
  1. 1. Acute myocardial infarction within the past 30 days prior to cardiac magnetic resonance imaging
  2. 2. Confirmed diagnosis of any significant non-coronary cardiac conditions below:
  3. 1. any severe-grade valvular heart disease,
  4. 2. left ventricular ejection fraction \<40% from any known non-coronary causes,
  5. 3. infiltrative cardiomyopathy,
  6. 4. hypertrophic cardiomyopathy,
  7. 5. pericardial disease with significant constriction, or
  8. 3. active pregnancy,
  9. 4. any competing conditions leading to an expected survival of \< 2 years
  10. 5. contraindication to vasodilator (regadenoson or adenosine)
  11. 6. metallic device or object that poses an magnetic resonance imaging safety hazard
  12. 7. metallic device with a high likelihood of non-diagnostic cardiac magnetic resonance images

Contacts and Locations

Study Contact

Raymond Y Kwong, MD, MPH
CONTACT
857-307-1960
rykwong@bwh.harvard.edu
Bobby Heydari, MD, MPH
CONTACT
bheydari@bwh.harvard.edu

Study Locations (Sites)

Brigham and Women's Hospital
Boston, Massachusetts, 02115
United States

Collaborators and Investigators

Sponsor: Brigham and Women's Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-27
Study Completion Date2029-03

Study Record Updates

Study Start Date2025-06-27
Study Completion Date2029-03

Terms related to this study

Keywords Provided by Researchers

  • Myocardial Blood Flow
  • Cardiac Magnetic Resonance
  • Quantitative perfusion
  • Cardiovascular Outcomes

Additional Relevant MeSH Terms

  • Ischemic Heart Disease (IHD)
  • Cardiac Magnetic Resonance Imaging
  • Myocardial Blood Flow