RECRUITING

Reducing Pain With Methadone and Ketamine in Liver Transplant

Description

The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery. The main questions it aims to answer are: * What impact does using methadone and ketamine during a deceased donor liver transplant have on pain after surgery? * Does the use of methadone and ketamine also have an impact on mental confusion (delirium) after surgery? Researchers will compare the use of methadone and ketamine to standard of care to see if the two drugs work to decrease pain and impact delirium after liver transplant. Participants will: * Receive either methadone and ketamine or standard of care during their deceased donor liver transplant. * Allow researchers to follow medical care throughout inpatient stay.

Conditions

Liver Transplantation
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Liver Transplantation

Study Overview

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Study Details

Study overview

The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery. The main questions it aims to answer are: * What impact does using methadone and ketamine during a deceased donor liver transplant have on pain after surgery? * Does the use of methadone and ketamine also have an impact on mental confusion (delirium) after surgery? Researchers will compare the use of methadone and ketamine to standard of care to see if the two drugs work to decrease pain and impact delirium after liver transplant. Participants will: * Receive either methadone and ketamine or standard of care during their deceased donor liver transplant. * Allow researchers to follow medical care throughout inpatient stay.

Randomized Clinical Trial of Methadone and Ketamine for Pain Management During Deceased Donor Liver Transplant

Reducing Pain With Methadone and Ketamine in Liver Transplant

Condition
Liver Transplantation
Intervention / Treatment

-

Contacts and Locations

Burlington

Lahey Hospital and Medical Center, Burlington, Massachusetts, United States, 01805

Burlington

Lahey Hospital and Medical Center, Burlington, Massachusetts, United States, 01805

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients ≥ 18 years of age at the time of LT.
  • * Undergoing LT from a deceased donor.
  • * Written informed consent obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study.
  • * Split liver transplantation (isolated right or left lobe).
  • * Acute liver failure (ALF) as the indication for LT.
  • * Simultaneous liver and kidney Transplant (SLK)
  • * Repeat liver transplant
  • * Sedation or high vasopressor use
  • * Subject is intubated and/or mechanically ventilated prior to entering the operating room for LT.
  • * Severe hepatic encephalopathy
  • * History of psychiatric disorders such as schizophrenia or bipolar mood disorders
  • * History of substance abuse or opioid maintenance therapies
  • * Any history of allergic reaction to methadone or ketamine
  • * History of prolonged QT syndrome or QTc in preoperative setting
  • * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Lahey Clinic,

Ryan Nazemian, MD, PhD, PRINCIPAL_INVESTIGATOR, Lahey Hospital and Medical Center, Department of Anesthesiology, Perioperative and Pain Medicine

Study Record Dates

2026-09-01