RECRUITING

Reducing Pain With Methadone and Ketamine in Liver Transplant

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn if using methadone and ketamine during an adult deceased donor liver transplant can help decrease pain after surgery. The main questions it aims to answer are: * What impact does using methadone and ketamine during a deceased donor liver transplant have on pain after surgery? * Does the use of methadone and ketamine also have an impact on mental confusion (delirium) after surgery? Researchers will compare the use of methadone and ketamine to standard of care to see if the two drugs work to decrease pain and impact delirium after liver transplant. Participants will: * Receive either methadone and ketamine or standard of care during their deceased donor liver transplant. * Allow researchers to follow medical care throughout inpatient stay.

Official Title

Randomized Clinical Trial of Methadone and Ketamine for Pain Management During Deceased Donor Liver Transplant

Quick Facts

Study Start:2025-06-30
Study Completion:2026-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06868589

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult patients ≥ 18 years of age at the time of LT.
  2. * Undergoing LT from a deceased donor.
  3. * Written informed consent obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study.
  1. * Split liver transplantation (isolated right or left lobe).
  2. * Acute liver failure (ALF) as the indication for LT.
  3. * Simultaneous liver and kidney Transplant (SLK)
  4. * Repeat liver transplant
  5. * Sedation or high vasopressor use
  6. * Subject is intubated and/or mechanically ventilated prior to entering the operating room for LT.
  7. * Severe hepatic encephalopathy
  8. * History of psychiatric disorders such as schizophrenia or bipolar mood disorders
  9. * History of substance abuse or opioid maintenance therapies
  10. * Any history of allergic reaction to methadone or ketamine
  11. * History of prolonged QT syndrome or QTc in preoperative setting
  12. * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data

Contacts and Locations

Study Contact

Ryan Nazemian, MD, PhD
CONTACT
781-813-0389
ryan.nazemian@lahey.org
Michael D Kaufman, MD
CONTACT
9787026578
michael.kaufman@bilh.org

Principal Investigator

Ryan Nazemian, MD, PhD
PRINCIPAL_INVESTIGATOR
Lahey Hospital and Medical Center, Department of Anesthesiology, Perioperative and Pain Medicine

Study Locations (Sites)

Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805
United States
Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805
United States

Collaborators and Investigators

Sponsor: Lahey Clinic

  • Ryan Nazemian, MD, PhD, PRINCIPAL_INVESTIGATOR, Lahey Hospital and Medical Center, Department of Anesthesiology, Perioperative and Pain Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-30
Study Completion Date2026-09-01

Study Record Updates

Study Start Date2025-06-30
Study Completion Date2026-09-01

Terms related to this study

Keywords Provided by Researchers

  • Liver Transplantation
  • Deceased Donor Liver Transplant
  • Postoperative Pain
  • Methadone
  • Ketamine
  • Perioperative Analgesia
  • Anesthesiology
  • Acute Pain
  • Transplant Surgery
  • Opioids

Additional Relevant MeSH Terms

  • Liver Transplantation