RECRUITING

Evaluation of Plasma Renin Concentrations in Cardiac Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery. Renin is a protein that may be elevated in response to low blood pressure or situations where organs do not receive sufficient oxygen. Renin may potentially be used as an indicator for specific treatments aimed to increase the blood pressure. This study will evaluate blood samples for renin concentration throughout the course of open heart surgery.

Official Title

Evaluation of Plasma Renin Concentrations in Cardiac Surgery

Quick Facts

Study Start:2025-04
Study Completion:2026-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06895213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult persons 18 years of age or greater.
  2. * Scheduled for an elective cardiac surgical procedure involving the use of cardiopulmonary bypass.
  1. * Surgery involving heart or lung transplantation or implant of a durable left ventricular assist device.
  2. * Emergency cardiac surgery.
  3. * Established diagnosis of any congenital heart disease.
  4. * End-stage kidney disease receiving kidney replacement therapy before surgery.

Contacts and Locations

Study Contact

Patrick M Wieruszewski, Pharm.D.
CONTACT
507-255-5732
wieruszewski.patrick@mayo.edu

Principal Investigator

Patrick M Wieruszewski, Pharm.D.
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Patrick M Wieruszewski, Pharm.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04
Study Completion Date2026-05

Study Record Updates

Study Start Date2025-04
Study Completion Date2026-05

Terms related to this study

Keywords Provided by Researchers

  • renin-angiotensin system
  • RAS
  • hypotension
  • perfusion
  • shock
  • blood pressure

Additional Relevant MeSH Terms

  • Cardiac Surgery With Cardiopulmonary Bypass