Evaluation of Plasma Renin Concentrations in Cardiac Surgery

Description

The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery. Renin is a protein that may be elevated in response to low blood pressure or situations where organs do not receive sufficient oxygen. Renin may potentially be used as an indicator for specific treatments aimed to increase the blood pressure. This study will evaluate blood samples for renin concentration throughout the course of open heart surgery.

Conditions

Cardiac Surgery With Cardiopulmonary Bypass

Study Overview

Study Details

Study overview

The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery. Renin is a protein that may be elevated in response to low blood pressure or situations where organs do not receive sufficient oxygen. Renin may potentially be used as an indicator for specific treatments aimed to increase the blood pressure. This study will evaluate blood samples for renin concentration throughout the course of open heart surgery.

Evaluation of Plasma Renin Concentrations in Cardiac Surgery

Evaluation of Plasma Renin Concentrations in Cardiac Surgery

Condition
Cardiac Surgery With Cardiopulmonary Bypass
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult persons 18 years of age or greater.
  • * Scheduled for an elective cardiac surgical procedure involving the use of cardiopulmonary bypass.
  • * Surgery involving heart or lung transplantation or implant of a durable left ventricular assist device.
  • * Emergency cardiac surgery.
  • * Established diagnosis of any congenital heart disease.
  • * End-stage kidney disease receiving kidney replacement therapy before surgery.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Patrick M Wieruszewski, Pharm.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2026-05