RECRUITING

Language Outcomes, Mechanisms, and Trajectories in Adults With and Without Developmental Language Disorder

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigators' overall objective is to characterize the long-term outcomes of Developmental Language Disorder (DLD) in adulthood and to identify specific cognitive mechanisms mediating these outcomes. To address their objectives, the investigators utilize a large, pre-existing dataset and participant pool from one of the most comprehensive examinations of DLD to date: the Iowa Longitudinal Study. The investigators will re-recruit subjects with DLD and with typical language from this historic cohort, who are now adults (30-35 years old). In Aim 1, the investigators will use measures from kindergarten through 10th grade and collect new outcome measures in adulthood to characterize the long-term outcomes of DLD. The investigators predict that adults with DLD will diverge from adults with TL in language skills that are more complex and higher-level language skills that are important for communication in the workplace. Further, the investigators predict a fanning effect: some children with DLD will "catch up" to their TL peers in adulthood, some will show evidence of a decline, and others will show stable trajectories. In Aim 2, the investigators measure real-time competition across written and spoken language using eye-tracking. According to speed of processing accounts adults with DLD may be slower than their TL peers to activate competitors and targets. According to working memory accounts adults with DLD will show sustained competitor activation. Further, the investigators predict that measures related to the dynamics of competition (speed of activation and timing of competitor suppression) will account for variation in language outcomes in adults.

Official Title

Language Outcomes, Mechanisms, and Trajectories in Adults With and Without Developmental Language Disorder

Quick Facts

Study Start:2023-04-17
Study Completion:2027-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06898671

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Years to 35 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults with Developmental Language Disorder (DLD) and those with typical language (TL) between the ages of 28 and 40 years who participated in the Iowa Longitudinal Study(NIH-DC-19-90 \& P50 DC002746; IRB# 200106051, "Collaboration on Specific Language Impairment".)
  2. * Aged 30-35
  3. * Normal or corrected to normal vision
  4. * Normal hearing
  1. * history of brain injury
  2. * history of neural developmental disabilities
  3. * not monolingual

Contacts and Locations

Study Contact

Kristi Hendrickson, PhD
CONTACT
319-335-8701
kristi-hendrickson@uiowa.edu
Emily Zrostlik, MA
CONTACT
319-467-0769
emily-phalen@uiowa.edu

Principal Investigator

Stewart McCauley, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa
Si On Yoon, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa
Philip Combiths, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa
J. Bruce Tomblin, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa
Jacob Oleson, PhD
PRINCIPAL_INVESTIGATOR
University of Iowa

Study Locations (Sites)

Wendell Johnson Speech and Hearing Center
Iowa City, Iowa, 52245
United States

Collaborators and Investigators

Sponsor: University of Iowa

  • Stewart McCauley, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa
  • Si On Yoon, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa
  • Philip Combiths, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa
  • J. Bruce Tomblin, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa
  • Jacob Oleson, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-17
Study Completion Date2027-07

Study Record Updates

Study Start Date2023-04-17
Study Completion Date2027-07

Terms related to this study

Keywords Provided by Researchers

  • Language Profiles
  • Language Processing
  • Adult Language Disorders
  • Typical Adult Language

Additional Relevant MeSH Terms

  • Developmental Language Disorder