ACTIVE_NOT_RECRUITING

Graded Exercise Hypoxia Testing

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.

Official Title

Graded Exercise Hypoxia Testing

Quick Facts

Study Start:2025-04-15
Study Completion:2028-04-24
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06901284

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. * Contraindications to exercise testing
  2. * Currently pregnant
  3. * Musculoskeletal or metabolic disease
  4. * Allergies to lidocaine
  5. * Body-mass index ≤18 or ≥35 kg·m-2
  6. * Pacemaker
  7. * No confounding cardiorespiratory disease
  8. * Persistent tobacco use (\>15 pack years)

Contacts and Locations

Principal Investigator

Michael Joyner, M.D.
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55902
United States
St. Mary's Hospital
Rochester, Minnesota, 55902
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Michael Joyner, M.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-15
Study Completion Date2028-04-24

Study Record Updates

Study Start Date2025-04-15
Study Completion Date2028-04-24

Terms related to this study

Additional Relevant MeSH Terms

  • Hypoxia