Graded Exercise Hypoxia Testing

Description

The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.

Conditions

Hypoxia

Study Overview

Study Details

Study overview

The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.

Graded Exercise Hypoxia Testing

Graded Exercise Hypoxia Testing

Condition
Hypoxia
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55902

Rochester

St. Mary's Hospital, Rochester, Minnesota, United States, 55902

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Contraindications to exercise testing
  • * Currently pregnant
  • * Musculoskeletal or metabolic disease
  • * Allergies to lidocaine
  • * Body-mass index ≤18 or ≥35 kg·m-2
  • * Pacemaker
  • * No confounding cardiorespiratory disease
  • * Persistent tobacco use (\>15 pack years)

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Michael Joyner, M.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2028-04-24