RECRUITING

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

Description

The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart (heart failure with preserved ejection fraction or HFpEF).

Conditions

Chest PainShortness of Breath
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Related Conditions:

Chest PainShortness of Breath

Study Overview

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Study Details

Study overview

The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart (heart failure with preserved ejection fraction or HFpEF).

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

Condition
Chest Pain
Intervention / Treatment

-

Contacts and Locations

Durham

Duke University Medical Center, Durham, North Carolina, United States, 27710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Clinically indicated exercise stress echo for the evaluation of exertional dyspnea or chest pain
  • * Age ≥50 years
  • * Known history of HFpEF
  • * LVEF \<50% on baseline echo study
  • * History of hypertrophic cardiomyopathy, amyloidosis, or pulmonary arterial hypertension, severe right ventricular dysfunction and severe valvular disease based on chart review or baseline echo study
  • * History of organ transplant (heart, kidney, liver, lungs)
  • * Severe pulmonary disease requiring ambulatory oxygen therapy
  • * End-stage renal disease requiring long-term renal replacement therapy
  • * Decompensated liver disease
  • * Conditions that prevent accurate assessment of E/e' ratio (mitral prosthetic valve, severe mitral annular calcification)
  • * Plan to use echo contrast agent during stress study (i.e. contrast agent needed for baseline study)
  • * Patients from outside Duke health system with no plan for long-term care at Duke

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Duke University,

Marat Fudim, MD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2026-01