RECRUITING

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

Conditions

Chest Pain Shortness of Breath Stress echocardiogram

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart (heart failure with preserved ejection fraction or HFpEF).

Official Title

Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction

Quick Facts

Study Start:2025-06

Study Completion:2026-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06927973

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Clinically indicated exercise stress echo for the evaluation of exertional dyspnea or chest pain * Age ≥50 years	* Known history of HFpEF * LVEF \<50% on baseline echo study * History of hypertrophic cardiomyopathy, amyloidosis, or pulmonary arterial hypertension, severe right ventricular dysfunction and severe valvular disease based on chart review or baseline echo study * History of organ transplant (heart, kidney, liver, lungs) * Severe pulmonary disease requiring ambulatory oxygen therapy * End-stage renal disease requiring long-term renal replacement therapy * Decompensated liver disease * Conditions that prevent accurate assessment of E/e' ratio (mitral prosthetic valve, severe mitral annular calcification) * Plan to use echo contrast agent during stress study (i.e. contrast agent needed for baseline study) * Patients from outside Duke health system with no plan for long-term care at Duke

Inclusion Criteria

Exclusion Criteria

* Clinically indicated exercise stress echo for the evaluation of exertional dyspnea or chest pain
* Age ≥50 years

* Known history of HFpEF
* LVEF \<50% on baseline echo study
* History of hypertrophic cardiomyopathy, amyloidosis, or pulmonary arterial hypertension, severe right ventricular dysfunction and severe valvular disease based on chart review or baseline echo study
* History of organ transplant (heart, kidney, liver, lungs)
* Severe pulmonary disease requiring ambulatory oxygen therapy
* End-stage renal disease requiring long-term renal replacement therapy
* Decompensated liver disease
* Conditions that prevent accurate assessment of E/e' ratio (mitral prosthetic valve, severe mitral annular calcification)
* Plan to use echo contrast agent during stress study (i.e. contrast agent needed for baseline study)
* Patients from outside Duke health system with no plan for long-term care at Duke

Contacts and Locations

Study Contact

Mark Kittipibul, MD

CONTACT

919-681-2723

mark.kittipibul@duke.edu

Principal Investigator

Marat Fudim, MD

PRINCIPAL_INVESTIGATOR

Duke University

Study Locations (Sites)

Duke University Medical Center

Durham, North Carolina, 27710

United States

Collaborators and Investigators

Sponsor: Duke University

Marat Fudim, MD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06

Study Completion Date2026-01

Study Record Updates

Study Start Date2025-06

Study Completion Date2026-01

Terms related to this study

Keywords Provided by Researchers

Stress echocardiogram

Additional Relevant MeSH Terms

Chest Pain
Shortness of Breath