RECRUITING

Sodium in the Skin and Atopic Dermatitis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.

Official Title

Sodium in the Skin and Atopic Dermatitis

Quick Facts

Study Start:2025-05-12
Study Completion:2028-08-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06998446

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Ages 50 years and above
  2. * Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy).
  1. * History of autoimmune disease.
  2. * Cardiac events in the last six months.
  3. * Impaired function of the liver or kidneys (glomerular filtration rate \<60ml/min).
  4. * Current use of medications that influence sodium excretion (e.g. thiazide diuretics, SGLT2 inhibitors and spironolactone), and/or chemotherapy or antibiotic treatment.
  5. * Currently receiving phototherapy or taking systemic medications for atopic dermatitis including cyclosporine, methotrexate, or other broad immunosuppressive medications.

Contacts and Locations

Study Contact

Jie Zhu, MD
CONTACT
415-502-0433
Jie.Zhu2@ucsf.edu
Katrina Abuabara, MD
CONTACT
415-514-9769
katrina.abuabara@ucsf.edu

Principal Investigator

Katrina Abuabara, M.D.
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

San Francisco VA Medical Center
San Francisco, California, 94115
United States
UCSF Mt Zion Campus
San Francisco, California, 94511
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Katrina Abuabara, M.D., PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-12
Study Completion Date2028-08-30

Study Record Updates

Study Start Date2025-05-12
Study Completion Date2028-08-30

Terms related to this study

Keywords Provided by Researchers

  • Sodium
  • Salt

Additional Relevant MeSH Terms

  • Eczema
  • Atopic Dermatitis