Sodium in the Skin and Atopic Dermatitis

Description

The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.

Conditions

Eczema, Atopic Dermatitis

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Study Overview

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Study Details

Study overview

The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.

Sodium in the Skin and Atopic Dermatitis

Sodium in the Skin and Atopic Dermatitis

Condition
Eczema
Intervention / Treatment

-

Contacts and Locations

San Francisco

San Francisco VA Medical Center, San Francisco, California, United States, 94115

San Francisco

UCSF Mt Zion Campus, San Francisco, California, United States, 94511

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 50 years and above
  • * Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy).
  • * History of autoimmune disease.
  • * Cardiac events in the last six months.
  • * Impaired function of the liver or kidneys (glomerular filtration rate \<60ml/min).
  • * Current use of medications that influence sodium excretion (e.g. thiazide diuretics, SGLT2 inhibitors and spironolactone), and/or chemotherapy or antibiotic treatment.
  • * Currently receiving phototherapy or taking systemic medications for atopic dermatitis including cyclosporine, methotrexate, or other broad immunosuppressive medications.

Ages Eligible for Study

50 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, San Francisco,

Katrina Abuabara, M.D., PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2028-08-30