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Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

Description

The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and supplements believed to have a positive effect on health.

Conditions

AgingCognitive DeclineOlder AdultsCardiovascularSedentary BehaviorsImmune SenescenceMotor Function
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Related Conditions:

AgingCognitive DeclineOlder AdultsCardiovascularSedentary BehaviorsImmune SenescenceMotor Function

Study Overview

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Study Details

Study overview

The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and supplements believed to have a positive effect on health.

Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

St. Louis

Washington University School of Medicine, St. Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 50-70
  • * Able to come to the research center for testing and intervention visits.
  • * Sedentary (no moderate exercise and no more than 15-minutes per day of light exercise (confirmed via interview with participants)).
  • * BMI≥27 or Body Roundness index ≥6
  • * Able to provide informed consent.
  • * Dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease unless minor eg one lacunar infarct with minimal/no impairment) per self-report or medical records.
  • * Medical conditions that suggest shortened lifespan (such as metastatic cancer), severe/uncontrolled psychiatric disorders or conditions that would prohibit safe participation.
  • * Unable to perform study assessments.
  • * Alcohol or substance abuse within 6 months per self-report or medical records.
  • * Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity.
  • * Any drug that interacts pharmacokinetically, or is contraindicated with study interventions (examples would include high-dose SSRI that should not be combined with vortioxetine)
  • * PI has discretion to exclude potential participants eg if their health status appears either too good or too poor to be amenable to intervention

Ages Eligible for Study

50 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington University School of Medicine,

Eric Lenze, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2026-05