RECRUITING

Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as well as medications and supplements believed to have a positive effect on health.

Official Title

Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study

Quick Facts

Study Start:2025-07
Study Completion:2026-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07000734

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Ages 50-70
  2. * Able to come to the research center for testing and intervention visits.
  3. * Sedentary (no moderate exercise and no more than 15-minutes per day of light exercise (confirmed via interview with participants)).
  4. * BMI≥27 or Body Roundness index ≥6
  5. * Able to provide informed consent.
  1. * Dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease unless minor eg one lacunar infarct with minimal/no impairment) per self-report or medical records.
  2. * Medical conditions that suggest shortened lifespan (such as metastatic cancer), severe/uncontrolled psychiatric disorders or conditions that would prohibit safe participation.
  3. * Unable to perform study assessments.
  4. * Alcohol or substance abuse within 6 months per self-report or medical records.
  5. * Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity.
  6. * Any drug that interacts pharmacokinetically, or is contraindicated with study interventions (examples would include high-dose SSRI that should not be combined with vortioxetine)
  7. * PI has discretion to exclude potential participants eg if their health status appears either too good or too poor to be amenable to intervention

Contacts and Locations

Study Contact

Aris Perez
CONTACT
314-747-8906
arisperez@wustl.edu
Angela Stevens
CONTACT
stevens.a@wustl.edu

Principal Investigator

Eric Lenze, MD
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine

Study Locations (Sites)

Washington University School of Medicine
St. Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • Eric Lenze, MD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07
Study Completion Date2026-05

Study Record Updates

Study Start Date2025-07
Study Completion Date2026-05

Terms related to this study

Additional Relevant MeSH Terms

  • Aging
  • Cognitive Decline
  • Older Adults
  • Cardiovascular
  • Sedentary Behaviors
  • Immune Senescence
  • Motor Function