RECRUITING

Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Description

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Conditions

Healthy Participants
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Study Overview

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Study Details

Study overview

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Effects of Fresh Mango as a Sugar Substitute Within High and Low Glycemic Breakfasts on Postprandial Glucose and Insulin

Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Condition
Healthy Participants
Intervention / Treatment

-

Contacts and Locations

Muncie

Health Professions Building, Ball State University, Muncie, Indiana, United States, 47306

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 - 45 years.
  • * Body mass index between 18.5-35.0 kg/m2
  • * Not pregnant (females only)
  • * Not postmenopausal (females only).
  • * Not been diagnosed with cardiovascular disease.
  • * Not been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  • * Not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • * Does not regularly take anti-inflammatory drugs (more than 2x week).
  • * Does not use glucose-lowering drugs (e.g., metformin)
  • * Does not use lipid-lowering drugs (e.g., statins)
  • * Does not use tobacco products or any illicit drugs.
  • * Does not have a pacemaker.
  • * Can consume mango, wheat, gluten, and milk.
  • * Can stay in a supine position in the dark for at least ten minutes.
  • * Not between the ages of 18-45
  • * Body mass index \< 18.5 kg/m2 or \>35.0 kg/m2
  • * Pregnant (females only)
  • * Postmenopausal status (females only).
  • * Been diagnosed with cardiovascular disease.
  • * Been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  • * Been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • * Regularly take anti-inflammatory drugs (more than 2x week).
  • * Uses glucose-lowering drugs (e.g., metformin)
  • * Uses lipid-lowering drugs (e.g., statins)
  • * Uses tobacco products or any illicit drugs.
  • * Have a pacemaker.
  • * Allergic to mango, wheat, gluten, and/or milk.
  • * Unable to lay in supine position in the dark for at least ten minutes.

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ball State University,

Bryant Keirns, PhD, PRINCIPAL_INVESTIGATOR, Ball State University

Study Record Dates

2026-12-01