RECRUITING

Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.

Official Title

Effects of Fresh Mango as a Sugar Substitute Within High and Low Glycemic Breakfasts on Postprandial Glucose and Insulin

Quick Facts

Study Start:2025-03-26
Study Completion:2026-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07045051

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18 - 45 years.
  2. * Body mass index between 18.5-35.0 kg/m2
  3. * Not pregnant (females only)
  4. * Not postmenopausal (females only).
  5. * Not been diagnosed with cardiovascular disease.
  6. * Not been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  7. * Not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  8. * Does not regularly take anti-inflammatory drugs (more than 2x week).
  9. * Does not use glucose-lowering drugs (e.g., metformin)
  10. * Does not use lipid-lowering drugs (e.g., statins)
  11. * Does not use tobacco products or any illicit drugs.
  12. * Does not have a pacemaker.
  13. * Can consume mango, wheat, gluten, and milk.
  14. * Can stay in a supine position in the dark for at least ten minutes.
  1. * Not between the ages of 18-45
  2. * Body mass index \< 18.5 kg/m2 or \>35.0 kg/m2
  3. * Pregnant (females only)
  4. * Postmenopausal status (females only).
  5. * Been diagnosed with cardiovascular disease.
  6. * Been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
  7. * Been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  8. * Regularly take anti-inflammatory drugs (more than 2x week).
  9. * Uses glucose-lowering drugs (e.g., metformin)
  10. * Uses lipid-lowering drugs (e.g., statins)
  11. * Uses tobacco products or any illicit drugs.
  12. * Have a pacemaker.
  13. * Allergic to mango, wheat, gluten, and/or milk.
  14. * Unable to lay in supine position in the dark for at least ten minutes.

Contacts and Locations

Study Contact

Bryant Keirns, PhD
CONTACT
765-285-8356
bryant.keirns@bsu.edu

Principal Investigator

Bryant Keirns, PhD
PRINCIPAL_INVESTIGATOR
Ball State University

Study Locations (Sites)

Health Professions Building, Ball State University
Muncie, Indiana, 47306
United States

Collaborators and Investigators

Sponsor: Ball State University

  • Bryant Keirns, PhD, PRINCIPAL_INVESTIGATOR, Ball State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-26
Study Completion Date2026-12-01

Study Record Updates

Study Start Date2025-03-26
Study Completion Date2026-12-01

Terms related to this study

Keywords Provided by Researchers

  • glycemia
  • insulinemia
  • fresh mango
  • vascular health

Additional Relevant MeSH Terms

  • Healthy Participants