RECRUITING

Oral Steroid Taper After Total Knee Arthroplasty

Description

This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).

Conditions

Osteoarthritis, Knee
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Related Conditions:

Osteoarthritis, Knee

Study Overview

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Study Details

Study overview

This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).

Effectiveness of an Oral Methylprednisolone Taper Following Primary Total Knee Arthroplasty

Oral Steroid Taper After Total Knee Arthroplasty

Condition
Osteoarthritis, Knee
Intervention / Treatment

-

Contacts and Locations

New York

Columbia University Medical Center, New York, New York, United States, 10032

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Any patient undergoing primary TKA with a diagnosis of osteoarthritis
  • * \> 18 years old
  • * Willingness to undergo randomization
  • * Patients who will be home by postoperative day (POD) #1 to start the dosing schedule that day (includes both ambulatory and POD #1 discharge patients)
  • * Reported chronic corticosteroid or opiate use prior to surgery
  • * Prior Open Surgery on the Ipsilateral Knee
  • * Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, septic arthritis, or postoperative traumatic arthritis
  • * American Society of Anesthesiologists (ASA) score ≥ 4
  • * Reported history of liver disease, renal disease, or diabetes mellitus
  • * Current systemic fungal infection or other local infection
  • * Immunocompromised or immunosuppressed
  • * Current peptic ulcer disease
  • * History of psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis
  • * Women with reported current pregnancy
  • * Known hypersensitivity to methylprednisolone
  • * ≤ 18 years old
  • * Inability to take oral medications
  • * Unable to provide consent

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Columbia University,

Study Record Dates

2027-06-20