RECRUITING

Oral Steroid Taper After Total Knee Arthroplasty

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).

Official Title

Effectiveness of an Oral Methylprednisolone Taper Following Primary Total Knee Arthroplasty

Quick Facts

Study Start:2025-06-20

Study Completion:2027-06-20

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT07070882

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Any patient undergoing primary TKA with a diagnosis of osteoarthritis * \> 18 years old * Willingness to undergo randomization * Patients who will be home by postoperative day (POD) #1 to start the dosing schedule that day (includes both ambulatory and POD #1 discharge patients)	* Reported chronic corticosteroid or opiate use prior to surgery * Prior Open Surgery on the Ipsilateral Knee * Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, septic arthritis, or postoperative traumatic arthritis * American Society of Anesthesiologists (ASA) score ≥ 4 * Reported history of liver disease, renal disease, or diabetes mellitus * Current systemic fungal infection or other local infection * Immunocompromised or immunosuppressed * Current peptic ulcer disease * History of psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis * Women with reported current pregnancy * Known hypersensitivity to methylprednisolone * ≤ 18 years old * Inability to take oral medications * Unable to provide consent

Inclusion Criteria

Exclusion Criteria

* Any patient undergoing primary TKA with a diagnosis of osteoarthritis
* \> 18 years old
* Willingness to undergo randomization
* Patients who will be home by postoperative day (POD) #1 to start the dosing schedule that day (includes both ambulatory and POD #1 discharge patients)

* Reported chronic corticosteroid or opiate use prior to surgery
* Prior Open Surgery on the Ipsilateral Knee
* Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, septic arthritis, or postoperative traumatic arthritis
* American Society of Anesthesiologists (ASA) score ≥ 4
* Reported history of liver disease, renal disease, or diabetes mellitus
* Current systemic fungal infection or other local infection
* Immunocompromised or immunosuppressed
* Current peptic ulcer disease
* History of psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis
* Women with reported current pregnancy
* Known hypersensitivity to methylprednisolone
* ≤ 18 years old
* Inability to take oral medications
* Unable to provide consent

Contacts and Locations

Study Contact

Jacqueline Lenahan

CONTACT

917-583-2885

jl5092@cumc.columbia.edu

Study Locations (Sites)

Columbia University Medical Center

New York, New York, 10032

United States

Collaborators and Investigators

Sponsor: Columbia University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-20

Study Completion Date2027-06-20

Study Record Updates

Study Start Date2025-06-20

Study Completion Date2027-06-20

Terms related to this study

Additional Relevant MeSH Terms

Osteoarthritis, Knee