RECRUITING

Natural History of Treated Neurocysticercosis and Long-Term Outcomes

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Neurocysticercosis is a brain disease due to the larval stage of the pork tapeworm (Taenia solium). The most common symptoms patient experience from infection inside the substance of the brain (parenchymal disease) are seizures and headaches. When the infection is either inside the fluid pockets inside the brain (ventricular disease) or in the space around the brain (subarachnoid disease) patients can have chronic headaches, relapsing aseptic meningitis, hydrocephalus, stroke, and may require neurosurgical intervention. The purpose of this study is to treat patients with anthelmintic therapy (praziquantel and/or albendazole) and anti-inflammatories in alignment with currently accepted best practices and guidelines, depending on the neurocysticercosis subtype. The purpose of the study is to better understand and characterize clinical, biologic, and management factors during treatment that influence long term outcomes. In order to understand this further we collect patient clinical information, patient survey responses, blood, urine samples, and additional cerebral spinal fluid if already being collected for clinical care.

Official Title

Natural History of Treated Neurocysticercosis and Long-Term Outcomes

Quick Facts

Study Start:1985-10-07
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00001205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:3 Years to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Aged 3 years and older.
  2. 2. Ability of participant (or legally authorized representative, LAR) to understand and the willingness to sign a written informed consent document.
  3. 3. Patients with proven or likely NCC
  4. 1. Patient with epidemiologic history compatible with possible exposure to NCC
  5. 2. Aged 18 years and older.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Perla M Adames Castillo, R.N.
CONTACT
(301) 402-8495
perla.adamescastillo@nih.gov
Elise M O'Connell, M.D.
CONTACT
(301) 761-5413
oconnellem@mail.nih.gov

Principal Investigator

Elise M O'Connell, M.D.
PRINCIPAL_INVESTIGATOR
National Institute of Allergy and Infectious Diseases (NIAID)

Study Locations (Sites)

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

  • Elise M O'Connell, M.D., PRINCIPAL_INVESTIGATOR, National Institute of Allergy and Infectious Diseases (NIAID)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date1985-10-07
Study Completion DateN/A

Study Record Updates

Study Start Date1985-10-07
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • Tapeworm
  • Taenia Solium
  • Neurocysticercosis
  • Natural History
  • Seizures
  • Aseptic Meningitis
  • Hydrocephalus

Additional Relevant MeSH Terms

  • Cysticercosis
  • Neurocysticercosis