RECRUITING

Evaluation of Patients With Liver Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed study aims to evaluate, investigate, and follow-up patients suffering from acute and chronic liver disease. The study will focus on understanding diseases affecting the liver. Patients participating in the study will first undergo a routine check-up as an outpatient. They will be asked to provide blood and urine samples for laboratory testing and will undergo an ultrasound of the liver. Ultrasound examinations use sound waves to determine the size and texture of the liver. After the initial visit subjects will be requested to follow-up once a year at the outpatient department for a similar check-up. Additional tests may be requested throughout the study to provide information for other research studies and individual consent will be requested. These tests may include liver biopsies, skin biopsies, and / or specialized blood, plasma, and lymphocyte examinations. Subjects that qualify for medications presently being studied may be offered the opportunity to benefit from experimental therapy....

Official Title

Evaluation of Patients With Liver Disease

Quick Facts

Study Start:1992-05-27
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00001971

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:2 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. \>=2 years of age.
  2. 2. Meets one of the following:
  3. 1. Suspected or evidence of acute or chronic liver disease on evaluation by a referring licensed independent practitioner (LIP), OR
  4. 2. At risk for acute or chronic liver disease
  5. 1. \>= 18 years of age.
  6. 2. In good general health as evidenced by medical history
  1. 1. Any chronic medical condition, including (but not limited to) heart, kidney, or lung diseases
  2. 2. Taking any regular medications or supplements (with the exception of regular multivitamins and/or oral contraceptives)
  3. 3. Average alcohol consumption \> 1 drink/day in past 6 months, per self-report
  4. 4. History of liver disease (with the exception of neonatal jaundice)
  5. 5. History of severe illness, infection or major surgery in the past year
  6. 6. History of cancer (with the exception of basal cell carcinoma resected \> 1 year prior to enrollment)
  7. 7. BMI \< 18 or BMI \>25
  8. 8. Hemoglobin \< 11 (women) or hemoglobin \< 12 (men)
  9. 9. ALT \>35 (men) or ALT \>25 (women)
  10. 10. Alkaline Phosphatase \>= 150
  11. 11. Bilirubin \>2 g/dL
  12. 12. HIV positive, Anti-HCV positive, HBsAg positive or Anti-HBc positive
  13. 13. Pregnancy
  14. 14. Inability to provide informed consent

Contacts and Locations

Study Contact

Patricia E Alcivar
CONTACT
(301) 435-6121
patricia.alcivar@nih.gov
T. Jake Liang, M.D.
CONTACT
(301) 496-1721
jakel@mail.nih.gov

Principal Investigator

T. Jake Liang, M.D.
PRINCIPAL_INVESTIGATOR
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Study Locations (Sites)

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  • T. Jake Liang, M.D., PRINCIPAL_INVESTIGATOR, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date1992-05-27
Study Completion DateN/A

Study Record Updates

Study Start Date1992-05-27
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • Hepatitis B
  • Hepatitis C
  • Hepatitis D
  • Chronic Hepatitis
  • Natural History
  • Liver Disease

Additional Relevant MeSH Terms

  • Hepatitis D
  • Hepatitis C
  • Hepatitis B
  • Liver Disease