RECRUITING

Study of New Magnetic Resonance Imaging Methods of the Brain

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function. MRI is a diagnostic tool that provides information about brain chemistry and physiology. This study will evaluate new MRI methods for monitoring blood flow to regions of the brain in response to simple tasks. The MRI machine used in this study is more powerful than those in most hospitals, permitting a higher visual resolution. Normal healthy volunteers over 18 years old may be eligible for this study. Candidates will be screened with a medical history and questionnaire, and a neurological examination. Study participants will have a yearly MRI scan. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. A lightweight circular or rectangular coil a device that improves the quality of the images may be placed on the head. The scan time varies from 20 minutes to 3 hours; most scans last between 45 and 90 minutes. During the scan, the subject may perform simple tasks, such as listening to tapes, tapping a finger, moving a hand, watching a screen, or smelling a fragrance. More complex tasks may require thinking about tones or pictures and responding to them by pressing buttons. Information from this study will be used to develop better imaging methods that will, in turn, permit a greater understanding of normal and abnormal brain behaviors.

Official Title

Characterization of Brain Morphology and Activity Using Functional and Anatomical MRI Contrast

Quick Facts

Study Start:2000-07-01
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00004577

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 120 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18 years of age and older
  2. * in good general health
  3. * able to understand the procedures and requirements and give informed consent
  1. 1. has any metal implant or objects of unknown identity or composition, or if it s known to be non-compatible with MRI, such as pacemakers, medication pumps, aneurysm clips, metallic prosthesis (such as heart valves or cochlear implants), certain orthopedic implants (pins and rods), shrapnel, or small metal fragments in the eye;
  2. 2. has claustrophobia;
  3. 3. cannot lie comfortably for up to 120 minutes;
  4. 4. underwent brain surgery or suffered a traumatic head trauma;
  5. 5. has migraines that require medication;
  6. 6. has ever been hospitalized for a psychiatric disorder;
  7. 7. has medical health problems such as pulmonary or airway disease, heart failure, coronary artery disease, and uncontrolled hypertension which would require physiological monitoring during the scan;
  8. 8. has a history of any medical condition that could result in an emergency medical situation while undergoing the MRI scan;
  9. 9. has hearing problems which would make it difficult to tolerate scanner noise;
  10. 10. is pregnant;
  11. 11. has body/make-up tattoos (e.g. lips, eyebrows, eyeliner). Each tattoo will be considered on a case-to-case basis, taking into account of the age and location of the tattoo;
  12. 12. has a sleep apnea diagnosis;
  13. 13. has a neurological disorder, such as Stroke, Parkinson s, and Epilepsy;
  14. 14. a member of the NINDS Laboratory of Functional and Molecular Imaging.

Contacts and Locations

Study Contact

Jeffrey H Duyn, Ph.D.
CONTACT
(301) 594-7305
duynjeff@ninds.nih.gov
Alan P Koretsky, Ph.D.
CONTACT
(301) 402-9659
koretskya@ninds.nih.gov

Principal Investigator

Alan P Koretsky, Ph.D.
PRINCIPAL_INVESTIGATOR
National Institute of Neurological Disorders and Stroke (NINDS)

Study Locations (Sites)

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

  • Alan P Koretsky, Ph.D., PRINCIPAL_INVESTIGATOR, National Institute of Neurological Disorders and Stroke (NINDS)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2000-07-01
Study Completion DateN/A

Study Record Updates

Study Start Date2000-07-01
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • Brain Morphology
  • Cerebral Blood Volume
  • Functional Imaging
  • Development
  • MEG
  • Natural History

Additional Relevant MeSH Terms

  • Healthy Volunteer
  • Magnetic Resonance Imaging
  • Healthy
  • fMRI
  • Brain Mapping
  • Adult