MRS Measurement of Glutamate and GABA Metabolism in Brain

Description

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA)....

Conditions

Normal Physiology

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Study Overview

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Study Details

Study overview

This study will use magnetic resonance spectroscopy (MRS) to measure in the brain the transfer of \[13\]C as it is naturally metabolized from glucose to specific chemical transmitters. From this method, we can measure the rate of production of an important excitatory neurotransmitter (glutamate) as well as an inhibitory neurotransmitter (GABA)....

MRS (Magnetic Resonance Spectroscopy) Measurement of Glutamate and GABA Metabolism in Brain

MRS Measurement of Glutamate and GABA Metabolism in Brain

Condition
Normal Physiology
Intervention / Treatment

-

Contacts and Locations

Bethesda

National Institutes of Health Clinical Center, Bethesda, Maryland, United States, 20892

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-65 years of age
  • * Able to give written informed consent
  • * Healthy based on medical history and physical exam
  • * Enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
  • * Any current Axis 1 diagnosis
  • * Clinically significant laboratory abnormalities
  • * Positive HIV test
  • * Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
  • * History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
  • * Prescription psychotropic medication; drug free less than 8 weeks (anticholinergics, benzodiazepine, fluoxetine, antipsychotics, and anticonvulsants)
  • * Serious medical illness as determined from H\&P or laboratory testing including Diabetes
  • * Inability to lie flat on camera bed for about two and a half hours
  • * Pregnant or breastfeeding
  • * Current substance use disorder based on DSM-5
  • * NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

National Institute of Mental Health (NIMH),

Li An, Ph.D., PRINCIPAL_INVESTIGATOR, National Institute of Mental Health (NIMH)

Study Record Dates

2030-03-11