RECRUITING

Establishing a Tumor Bank in Families With Multiple Lymphoproliferative Malignancies

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to investigate possible genetic factors that contribute to the development of lymphomas. The databank will be used to determine whether familial lymphomas have unique genetic characteristics different from sporadic lymphomas and to attempt to identify a gene that confers an increased risk of lymphoma.

Official Title

Establishing a Tumor Bank and Initial Analysis of Germline and Tumor-Related Genetic Alterations in Families With Multiple Lymphoproliferative Malignancies

Quick Facts

Study Start:2004-08-09
Study Completion:2033-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00131014

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Any individual diagnosed with non-Hodgkin's lymphoma or Hodgkin's disease or chronic lymphocytic leukemia (CLL), who has a 1st degree relative (parent, sibling or child) with a lymphoproliferative disorder; or families in which the individual has a lymphoproliferative disorder, and an unusual clustering of frequent or premature solid tumors is also observed.
  2. * Family members of the individual, either affected or unaffected with lymphoma, who are contacted by the individual and agree to participate in the study.
  3. * Deceased family members may be included in the study. Public records such as death certificates may be used to confirm the history. Consent for medical records or tissue blocks will be obtained from the deceased family member's next of kin. The hierarchy of relatives defined as next of kin is spouse, offspring, parents and siblings. Archived tissue samples may be used for genetic research.
  4. * Age \> 18 years
  1. * Subjects without a family history of lymphoma

Contacts and Locations

Study Contact

Celeste Carey, MS
CONTACT
857-215-1646
celeste_carey@dfci.harvard.edu
Jennifer Brown, MD PhD
CONTACT
617-632-4564
Jennifer_Brown@dfci.harvard.edu

Principal Investigator

Jennifer R. Brown, MD, PhD
PRINCIPAL_INVESTIGATOR
Dana-Farber Cancer Institute

Study Locations (Sites)

Dana-Farber Cancer Institute
Boston, Massachusetts, 02115
United States

Collaborators and Investigators

Sponsor: Dana-Farber Cancer Institute

  • Jennifer R. Brown, MD, PhD, PRINCIPAL_INVESTIGATOR, Dana-Farber Cancer Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2004-08-09
Study Completion Date2033-01

Study Record Updates

Study Start Date2004-08-09
Study Completion Date2033-01

Terms related to this study

Keywords Provided by Researchers

  • Non-Hodgkin's Lymphoma
  • Hodgkin's disease
  • Chronic Lymphocytic Leukemia
  • Lymphoproliferative disorder
  • Genetics

Additional Relevant MeSH Terms

  • Non-Hodgkin's Lymphoma
  • Hodgkin's Disease
  • Leukemia, Lymphocytic, Chronic
  • Lymphoproliferative Disorders