Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

Description

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Conditions

Heart Failure, Congestive

Study Overview

Study Details

Study overview

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress

Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

Condition
Heart Failure, Congestive
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins Medical Institutions, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * age \> 18 years
  • * Healthy subjects: no history of heart disease
  • * Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40%
  • * Left ventricular hypertrophy: wall thickness \>1.2cm
  • * Coronary artery disease: \>50% coronary lesion or positive stress test
  • * contraindication to MRI

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Robert G. Weiss, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2028-08