RECRUITING

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

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Conditions

Diabetic NephropathyDiabetes MellitusDiabetic Kidney DiseaseAlbuminuriaAmerican IndiansComplicationsGeneticsLinkageType 2 DiabetesNatural History

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Family Investigation of Nephropathy and Diabetes (FIND) is a multicenter study designed to identify genetic determinants of diabetic kidney disease. FIND will be conducted in eleven centers and in many ethnic groups throughout the United States. Two different strategies will be used to localize genes predisposing to kidney disease: a family-based genetic linkage study and a case-control study that utilizes admixture linkage disequilibrium. The center based at the Phoenix office of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK-Phoenix) will conduct family-based linkage studies among American Indian populations in the southwestern United States. Participants (index cases) with diabetes and kidney disease will initially be recruited, and their parents and siblings will also be invited to participate. Genetic material from these participants will be used to genotype markers throughout the genome. Linkage analysis will be conducted to identify particular chromosomal regions containing genes that influence susceptibility to diabetic kidney disease. Linkage analyses will also be used to identify genes influencing traits related to diabetic kidney disease, such as serum creatinine, urinary protein excretion, plasma glucose levels, blood pressure and blood lipid levels. Regions that show evidence for linkage will then be examined in more detail, with both genetic linkage and association studies, to attempt to identify the specific genes that influence diabetic kidney disease, or related traits. The identification of genes that influence susceptibility to diabetic kidney disease will lead to a better understanding of how kidney disease develops. In the long run, this may lead to improved treatment and prevention of diabetic kidney disease....

Official Title

Family Investigation of Nephropathy and Diabetes (F.I.N.D.)

Quick Facts

Study Start:2001-03-07
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00342927

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Biopsy proven diabetic nephropathy (by medical record review):
  2. 1. Nodular and/or diffuse increases in the mesangial matrix accumulation; and
  3. 2. Thickened glomerular basement membranes and/or arteriolar hyalinization; and
  4. 3. Absence of mesangial immunoglobulin or paraprotein deposits by immunoflorecscence microscopy, absence of amyloid deposits by Congo Red staining or electron microscopy, absence of electron dense deposits within the glomerular basement membrane or glomerular capillary subendothelial space; and
  5. 4. Overt proteinuria, defined as ACR greater than or equal to 300 mg/g, urinary protein creatinine ratio greater than or equal to 0.5 g/g, urinary albumin excretion greater than or equal to 300 mg/24 hr, or urinary protein excretion greater than or equal to 0.5 g/24 hr.
  6. 2. ESRD (including transplant) from presumed diabetic nephropathy:
  7. 3. Patient with presumed diabetic nephropathy but not ESRD:
  8. 1. The index case and both parents, or
  9. 2. The index case and at least one other affected sibling who has diabetes and renal disease, or
  10. 3. The index case and at least one unaffected sibling, defined as an individual who has had diabetes for at least 10 years and who has no renal disease (based on evidence obtained from the medical record and from the FIND examination.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Robert L Hanson, M.D.
CONTACT
(602) 200-5207
rhanson@phx.niddk.nih.gov

Principal Investigator

Robert L Hanson, M.D.
PRINCIPAL_INVESTIGATOR
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Study Locations (Sites)

NIDDK, Phoenix
Phoenix, Arizona, 85014
United States

Collaborators and Investigators

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  • Robert L Hanson, M.D., PRINCIPAL_INVESTIGATOR, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2001-03-07
Study Completion DateN/A

Study Record Updates

Study Start Date2001-03-07
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • American Indians
  • Complications
  • Genetics
  • Linkage
  • Type 2 Diabetes
  • Natural History
  • Diabetic Kidney Disease

Additional Relevant MeSH Terms

  • Diabetic Nephropathy
  • Diabetes Mellitus
  • Diabetic Kidney Disease
  • Albuminuria