Biliary Atresia Study in Infants and Children

Description

Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA; To identify polymorphisms that may be important in disease progression such as HLA polymorphisms; To characterize the natural history of the older, non-transplanted child with BA.

Conditions

Biliary Atresia

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Study Overview

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Study Details

Study overview

Little is known about the factors that cause biliary atresia nor the factors that influence disease progression. The purpose of this study is to collect the pertinent clinical information, genetic material and body fluid samples to enable investigators to address the following aims: To identify the gene or genes implicated in the etiology of BA; To identify polymorphisms that may be important in disease progression such as HLA polymorphisms; To characterize the natural history of the older, non-transplanted child with BA.

Biliary Atresia Study in Infants and Children (BASIC)

Biliary Atresia Study in Infants and Children

Condition
Biliary Atresia
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Children's Hospital of Los Angeles, Los Angeles, California, United States, 90027

San Francisco

University of California at San Francisco, San Francisco, California, United States, 94143

Aurora

Children's Hospital Colorado, Aurora, Colorado, United States, 80045

Atlanta

Children's Healthcare of Atlanta - Emory University, Atlanta, Georgia, United States, 30322

Chicago

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States, 60614

Indianapolis

Riley Children's Hospital, Indianapolis, Indiana, United States, 46202

Baltimore

Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 21287

Saint Louis

Washington University School of Medicine, Saint Louis, Missouri, United States, 63110

New York

Mount Sinai Medical Center, New York, New York, United States, 10029

Cincinnati

Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Participants need to have a confirmed diagnosis of BA determined by chart review including review of pertinent diagnostic biopsy reports, radiologic reports and surgical reports (if surgery was performed).
  • 2. Participants need to be \>6 months of age up to and equal to the age of 20 (participants enrolled at 20 years of age will have one visit).
  • 3. Participants either have their native liver or have a confirmed liver transplantation.
  • 4. Parent, guardian or participant (if 18 years of age or older) is willing to provide informed consent and, when appropriate, the participant is willing to assent.
  • 1. Currently participating in the ChiLDReN study PROBE
  • 2. Inability to confirm original diagnostic evaluation of biliary atresia
  • 3. Inability or unwillingness of family or participant to participate in all scheduled visits.

Ages Eligible for Study

6 Months to 20 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Arbor Research Collaborative for Health,

Vicky Ng, MD, STUDY_CHAIR, The Hospital for Sick Children, Toronto, ON, Canada

Ed Doo, MD, STUDY_DIRECTOR, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

John C Magee, MD, PRINCIPAL_INVESTIGATOR, University of Michigan

Lisa Henn, PhD, PRINCIPAL_INVESTIGATOR, Arbor Research Collaborative for Health - Data Coordinating Center

Averell Sherker, MD, STUDY_DIRECTOR, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Study Record Dates

2029-05