Identifying Genetic Causes of IC/BPS

Description

Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another. In this study, we are collecting genetic material via blood or saliva and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS. We are enrolling inviduals with IC/BPS and their family members (family members with and without IC like symptoms). Travel to Boston not required.

Conditions

Interstitial Cystitis, Bladder Pain Syndrome

Study Overview

Study Details

Study overview

Interstitial cystitis (IC), also called Bladder Pain syndrome (BPS) is a common condition with no known cause or cure. Twin studies and family accounts have suggested that the condition may be genetic or passed down (inherited) from one generation to another. In this study, we are collecting genetic material via blood or saliva and medical information from families in North America in an attempt to identify genetic factors that may cause IC/BPS. We are enrolling inviduals with IC/BPS and their family members (family members with and without IC like symptoms). Travel to Boston not required.

Genetic Studies in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

Identifying Genetic Causes of IC/BPS

Condition
Interstitial Cystitis
Intervention / Treatment

-

Contacts and Locations

Boston

Boston Children's Hospital (BCH), Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of IC/BPS
  • * Males and females of any age
  • * Urinary frequency - more than 1X/hour, and/or
  • * Dysuria, and/or
  • * Pelvic, suprapubic, or abdominal pain - for 3 months or longer
  • * Nocturia
  • * Normal urinary stream (by history)
  • * No evidence of active bacterial UTI (no pyuria \& negative urinary culture for last 3 months)
  • * First degree relative of someone with above symptoms
  • * Major structural/anatomical urinary tract abnormalities by ultrasound
  • * Underlying inborn conditions affecting the urinary tract
  • * Surgery/chemotherapy affected pelvic area
  • * GI or GU cancers
  • * Severe Constipation in children only

Ages Eligible for Study

1 Year to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Boston Children's Hospital,

Catherine Brownstein, Ph.D., PRINCIPAL_INVESTIGATOR, Boston Children's Hosptial

Study Record Dates

2030-12-31