RECRUITING

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

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Conditions

Mood DisordersAnxiety DisordersMorphometryBOLDfMRISpectrometryRelaxometryNatural HistoryHealthy VolunteerHV

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Researchers believe that depression and anxiety disorders may cause structural and functional changes in the brain. This study will optimize the way MRI scans are collected to look at brain structure and examine how the brain behaves while subjects perform particular tasks. Healthy volunteers and individuals with major depressive disorder may be eligible for this study. Participants undergo magnetic resonance imaging (MRI) and neuropsychological testing. : Individuals will be asked to participate in an MRI study on one of several scanners. The scanner used will measure blood flow in the brain, concentrations of certain chemicals in the brain, or magnetic properties of the brain. The scan may involve They watching a screen presenting images or doing a task in which they respond to pictures or sounds. Participants may be asked to return for additional scans. The study also involves neuropsychological tests, which assess cognitive performance. Often, people with mood disorders have subtle changes in performance on these tests that allow researchers to pinpoint where brain abnormalities occur. Before the tests can be used in patients, they must be validated by using healthy subjects. These tests are presented either orally, in written form, or on a computer....

Official Title

Development of Functional and Structural Magnetic Resonance Imaging Techniques for the Study of Mood and Anxiety Disorders

Quick Facts

Study Start:2006-12-06
Study Completion:N/A
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00397111

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male and female subjects between 18 and 65 years of age
  2. * Subjects must be able to give written informed consent prior to participation in this study.
  3. * Subjects who do not currently meet and have never met criteria for any major psychiatric disorder, and who have no known first degree relatives with mood disorders.
  4. * For cognitive experiments utilizing language stimuli only native English speakers will be enrolled.
  5. * Male and female subjects between 18 and 65 years of age.
  6. * Subjects have been found eligible for other ETPB research protocols according to 01-M-0254.
  7. * Subjects must fulfill DSM-IV or V criteria for Major Depression based on clinical assessment and confirmed by a structured diagnostic interview (SCID-P).
  8. * Subjects must be able to give written informed consent prior to participation in this study.
  9. * For cognitive experiments utilizing language stimuli, only native English speakers will be enrolled.
  1. * Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology, or taking any medication that is likely to influence the imaging parameters-of-interest within 3 weeks of scanning.
  2. * Women who are pregnant or breastfeeding. Subjects will undergo pregnancy testing no more than 24 hours prior to scanning.
  3. * Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.
  4. * A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).
  5. * A current NIMH employee/staff or their immediate family member.
  6. * Presence of Axis 1 psychiatric diagnosis other than Major Depression or an Axis 2 disorder
  7. * Subjects with major medical or neurological disorders expected to influence cognitive function or are taking any drugs likely to affect mood or cognitive function within 1 week of study participation. Depressed subjects will not be tapered/withdrawn from medications under this study.
  8. * A history of drug or alcohol abuse within 1 year or a lifetime history of drug or alcohol dependence (DSM-IV) or alcohol use disorder (DSM-V equivalent).
  9. * A current NIMH employee/staff or their immediate family member
  10. * Subjects with major medical or neurological disorders expected to influence cerebral blood flow or morphology.
  11. * Women who are pregnant or breastfeeding. Subjects will undergo pregnancy testing no more than 24 hours prior to scanning.
  12. * Subjects with contraindication to MRI scanning such as aneurysm clips, implanted neural stimulator, implanted cardiac pacemaker or auto-defibrillator, cochlear implant, or ocular foreign body.

Contacts and Locations

Study Contact

Allison C Nugent, Ph.D.
CONTACT
(301) 451-8863
moodresearch@mail.nih.gov

Principal Investigator

Allison C Nugent, Ph.D.
PRINCIPAL_INVESTIGATOR
National Institute of Mental Health (NIMH)

Study Locations (Sites)

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Institute of Mental Health (NIMH)

  • Allison C Nugent, Ph.D., PRINCIPAL_INVESTIGATOR, National Institute of Mental Health (NIMH)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2006-12-06
Study Completion DateN/A

Study Record Updates

Study Start Date2006-12-06
Study Completion DateN/A

Terms related to this study

Keywords Provided by Researchers

  • Morphometry
  • BOLD
  • fMRI
  • Spectrometry
  • Relaxometry
  • Natural History
  • Healthy Volunteer
  • HV

Additional Relevant MeSH Terms

  • Mood Disorders
  • Anxiety Disorders