RECRUITING

Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer. The investigators hypothesis is that systematic collection of data on the natural history of GERD and BE patients and risk factors for development of BE in patients with chronic GERD and progression of BE to dysplasia and adenocarcinoma will provide useful information to develop a decision model for risk stratification and risk reduction strategies in these patients. As of March 17, 2011, 585 patients have consented at the Kansas City VA Medical Center.

Official Title

A Prospective Study To Define The Role Of Various Factors In Development And Progression Of Gastroesophageal Reflux Disease (GERD) And Barrett's Esophagus And The Creation Of A Registry.

Quick Facts

Study Start:2006-01
Study Completion:2029-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00574327

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Kansas City VA Patients with confirmed BE with and without dysplasia and patients with reflux disease (patients/cases); patients with other indicators for endoscopy such as anemia, weight loss, diarrhea, but without GERD and PE (controls).
  1. * Patients with uncontrolled significant comorbidities such as cardiovascular, pulmonary, renal, hepatic or metabolic diseases.
  2. * Presence of anticoagulation that would increase risk from biopsies
  3. * Patients unable to provide history
  4. * Patients with dyspepsia

Contacts and Locations

Study Contact

April D Higbee, RN, BSN
CONTACT
816-861-4700
april.higbee@va.gov
Carly Campbell, MS
CONTACT
816-861-4700
Carlissa.Campbell@va.gov

Principal Investigator

Prateek Sharma, MD
PRINCIPAL_INVESTIGATOR
Department of Veterans Affairs Medical Center of Kansas City

Study Locations (Sites)

Department of Veterans Affairs Medical Center
Kansas City, Missouri, 64128
United States

Collaborators and Investigators

Sponsor: Midwest Biomedical Research Foundation

  • Prateek Sharma, MD, PRINCIPAL_INVESTIGATOR, Department of Veterans Affairs Medical Center of Kansas City

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2006-01
Study Completion Date2029-01

Study Record Updates

Study Start Date2006-01
Study Completion Date2029-01

Terms related to this study

Keywords Provided by Researchers

  • Role
  • Registry
  • Barrett's Esophagus

Additional Relevant MeSH Terms

  • Barrett's Esophagus
  • Gastroesophageal Reflux Disease
  • Esophageal Adenocarcinoma