PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

Description

The purpose of this study is to determine if normally occurring variations in a specific gene called PTGS-1 are associated with an increased risk of narrowing of the ductus arteriosus from exposure to over-the-counter pain medicines (NSAIDs).

Conditions

Persistent Pulmonary Hypertension of the Newborn

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine if normally occurring variations in a specific gene called PTGS-1 are associated with an increased risk of narrowing of the ductus arteriosus from exposure to over-the-counter pain medicines (NSAIDs).

Prostaglandin G/H Synthase-1 (PTGS1) Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn (PPHN)

PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

Condition
Persistent Pulmonary Hypertension of the Newborn
Intervention / Treatment

-

Contacts and Locations

Milwaukee

Children's Wisconsin, Milwaukee, Wisconsin, United States, 53226

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Infants born greater than or equal to 34 weeks gestational age diagnosed with PPHN and normal, healthy infants born greater than or equal to 34 weeks gestational age.
  • * Patients will be excluded if they are diagnosed with lethal congenital anomalies
  • * structural congenital heart disease except presence of patent ductus arteriosus (PDA) or patent foramen ovale
  • * structural gastrointestinal tract abnormality that could interfere with meconium passage
  • * congenital anomalies such as diaphragmatic hernia, Potter's syndrome, or pulmonary hypoplasia

Ages Eligible for Study

to 12 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Medical College of Wisconsin,

G. Ganesh Konduri, MD, PRINCIPAL_INVESTIGATOR, Medical College of Wisconsin

Study Record Dates

2026-12