RECRUITING

PTGS1 Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn

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Conditions

Persistent Pulmonary Hypertension of the NewbornPPHNPTGS1NSAID

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine if normally occurring variations in a specific gene called PTGS-1 are associated with an increased risk of narrowing of the ductus arteriosus from exposure to over-the-counter pain medicines (NSAIDs).

Official Title

Prostaglandin G/H Synthase-1 (PTGS1) Genetic Variation and Increased Risk for Persistent Pulmonary Hypertension of the Newborn (PPHN)

Quick Facts

Study Start:2006-01
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00710177

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified to 12 Months
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * Infants born greater than or equal to 34 weeks gestational age diagnosed with PPHN and normal, healthy infants born greater than or equal to 34 weeks gestational age.
  1. * Patients will be excluded if they are diagnosed with lethal congenital anomalies
  2. * structural congenital heart disease except presence of patent ductus arteriosus (PDA) or patent foramen ovale
  3. * structural gastrointestinal tract abnormality that could interfere with meconium passage
  4. * congenital anomalies such as diaphragmatic hernia, Potter's syndrome, or pulmonary hypoplasia

Contacts and Locations

Study Contact

G. Ganesh Konduri, MD
CONTACT
414-266-6820
gkonduri@mcw.edu
Kathleen M Meskin, BSN
CONTACT
414-337-7171
kmeskin@mcw.edu

Principal Investigator

G. Ganesh Konduri, MD
PRINCIPAL_INVESTIGATOR
Medical College of Wisconsin

Study Locations (Sites)

Children's Wisconsin
Milwaukee, Wisconsin, 53226
United States

Collaborators and Investigators

Sponsor: Medical College of Wisconsin

  • G. Ganesh Konduri, MD, PRINCIPAL_INVESTIGATOR, Medical College of Wisconsin

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2006-01
Study Completion Date2026-12

Study Record Updates

Study Start Date2006-01
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • PPHN
  • PTGS1
  • NSAID

Additional Relevant MeSH Terms

  • Persistent Pulmonary Hypertension of the Newborn