RECRUITING

Systemic Lupus Erythematosus in Gullah Health

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies, multiple organ involvement, and diverse clinical symptoms and immunologic manifestations. African Americans are at a disproportionately higher risk of developing SLE, develop SLE at an earlier age, and have increased morbidity and mortality compared with European Americans. Our central study hypothesis is that there are specific genetic factors that interact with environmental exposures leading to the development of SLE. The African American Gullah population from the Sea Islands of South Carolina and Georgia are unique in their genetic homogeneity with minimal non-African genetic admixture, making them an ideal cohort to address questions of environmental and genetic influence on the development and progression of SLE.

Official Title

Systemic Lupus Erythematosus in Gullah Health

Quick Facts

Study Start:2003-04
Study Completion:2027-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT00756769

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:2 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 2 years and above;
  2. * Self-identified as African-American "Gullah" from the Sea Island region of South Carolina;
  3. * Have had at least 4 of the 11 diagnostic criteria for SLE as designated by the American College of Rheumatology (ACR), be a relative of a known SLE patient, or be an unrelated healthy Gullah control;
  4. * Ability to speak and understand English;
  5. * Ability and willingness to give informed consent
  1. * Race defined by participant as other than Black or African-American;
  2. * Being a prisoner, mentally ill patient, or institutionalized individual;
  3. * Unwilling or unable to give informed consent

Contacts and Locations

Study Contact

Diane L. Kamen, MD, MSCR
CONTACT
843-792-4825
kamend@musc.edu

Principal Investigator

Diane L. Kamen, MD, MSCR
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Diane L. Kamen, MD, MSCR, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2003-04
Study Completion Date2027-06

Study Record Updates

Study Start Date2003-04
Study Completion Date2027-06

Terms related to this study

Keywords Provided by Researchers

  • African Americans

Additional Relevant MeSH Terms

  • Systemic Lupus Erythematosus