Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Description

The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or heart failure.

Conditions

Acute Decompensated Heart Failure, Heart Failure

Study Overview

Study Details

Study overview

The purpose of this research is to determine if two proteins in the blood are increased during acute heart failure. These two proteins are produced when the heart becomes dysfunctional and unable to contract normally. They may then be released into the blood and be detected by standard method in the research laboratory. Thus, the purpose of this study is to determine the relation between the change of these two proteins in the blood and the occurrence of acute heart failure. At this time, detection of an increase in these proteins in the blood is not known to be associated with any disease or heart failure.

Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Condition
Acute Decompensated Heart Failure
Intervention / Treatment

-

Contacts and Locations

Farmington

University of Connecticut Health Center, Farmington, Connecticut, United States, 06030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Individuals aged \>18yrs
  • * stable or decompensated heart failure, irrespective of LVEF
  • * decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites
  • * Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures)
  • * Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls.
  • * Subjects who are unable to give informed consent
  • * Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment
  • * Pregnant subjects are not excluded

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

UConn Health,

Bruce T. Liang, M.D., PRINCIPAL_INVESTIGATOR, UConn Health

Study Record Dates

2025-09